CAS: 16691-43-3; 3-Amino-1H-1,2,4-Triazole-5-Thiol

相似化合物

3179-31-5 1750-12-5 27105-98-2

上下游产品

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专利信息

专利号:US-9828386-B2
优先权日:2013-11-15
标题:Sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof
发明人：TANG YAJIE; LI JIANLONG; ZHAO WEI; LI HONGMEI
权利人:UNIV HUBEI TECHNOLOGY
摘要:The present invention discloses a sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof. The present invention introduces a rigid aromatic heterocyclic compound, as well as a further sulfonamidated product of 3-amino-5-mercapto-1,2,4-triazole, 2-amino-5-mercapto-1,3,4-thiadiazole, 4-methylbenzenesulfonyl chloride, or 4-methoxybenzenesulfonyl chloride as a substituent group, into position 4 of the C-ring of podophyllotoxin or 4′-demethylepipodophyllotoxin to obtain the podophyllotoxin derivative shown in formula (V), said derivative having significantly increased antitumor activity and reduced toxic side effects. Experiments on in vitro tumor cell inhibition indicate that the antitumor activity of the compound of formula (V) of the present invention is significantly higher than the antitumor activity of podophyllotoxin or 4′-demethylepipodophyllotoxin.

专利号:US-10954197-B2
优先权日:2017-03-08
标 题 :Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer
发明人：YOGEESWARI PERUMAL
权利人:YOGEES BIOINNOVATIONS PRIVATE LTD
摘要:Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer are provided. More particularly, the embodiments relate to the design and synthesis of inhibitors of Cathepsin D, which exhibits antiproliferative activity and also inhibits angiogenesis. Also provided are compositions thereof for treating breast cancer.

专利号:US-5064953-A
优先权日:1983-12-29
标 题:Intermediates cephalosporin derivatives
发明人：OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI
权利人:MOCHIDA PHARM CO LTD
摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

专利号:JP-6856608-B2
优先权日:2014-02-24
标 题:Direct electrochemical synthesis of dope conductive polymer on metal alloy

专利号:US-4888332-A
优先权日:1983-12-29
标 题 :Cephalosporin derivatives
发明人：OHNISHI HARUO; KOSUZUME HIROSHI; MIZOTA MASAHIRO; SUZUKI YASUO; MOCHIDA EI
权利人:MOCHIDA PHARM CO LTD
摘要:The present invention relates to novel cephalosporin derivatives, processes for preparing thereof, compositions for preventing and/or treating infectious diseases which comprise the novel cephalosporin derivatives as active components, and the intermediate compounds in the synthesis of cephalosporin derivatives and processes for producing thereof. The novel cephalosporin derivatives according to the present invention contain condensed heterocyclic groups, particularly a triazolopyrimidine ring or a thiadiazolopyrimidine ring as substituents at the 3-position of the cephem skeleton, and a hydroxyimino, an alkyloxyimino or an acyloxyimino moiety as substituents at the 7-position of the cephem skeleton. The compounds of the present invention containing the aforementioned substituents have a strong antibacterial activity against gram-negative bacteria and also against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. These compounds are extremely useful for the treatment of infectious diseases.

专利号:EP-3396028-B1
优先权日:2014-02-24
标 题 :Direct electrochemical synthesis of doped conductive polymers on metal alloys