CAS: 42055-15-2; 3-(Methylamino)Propan-1-Ol

相似化合物

157887-82-6 58885-58-8 89448-83-9

上下游产品

trimethylene oxide methylamine methyl-carbamic acid-(3-chloro-propyl ester) allyl alcohol -3-methyl-2H-1,3,2-oxazaphosphorinan-1-oxid2--3-methyl-2H-1,3,2-oxazaphosphorinan-1-oxid N-methyl-N-nitroso-3-hydroxypropylamine -propanol-(1)3-3-Phenyl-1-methyl-thioureido-propanol-(1) (3-Hydroxy-propyl)-methyl-prop-2-inyl-amin

3-氯-1-丙醇置于sodium Iodide 甲胺,Potassium Carbonate体系中,用 水 作为反应溶剂,化学反应 17.0H,反应生成 3-(甲胺基)-1-丙醇
参考文献:Process For Preparation Of Substituted Amino Alcohols
标题:Process For Preparation Of Substituted Amino Alcohols
摘要:提供了一种制备取代氨基醇ho-(Ch2)N-nr1R2的过程,其中x为cl,Br或i的卤代醇ho-(Ch2)N-x与胺hnr1R2在水中作作为反应溶剂反应,反应温度范围为约20oc到约90°C,在需要时可在碘化物源金属碘化物的催化下进行.卤代醇在制备6-[(取代)苯基]-三唑嘧啶化合物中有用,该化合物在癌症治疗中有用.

专利信息

专利号:US-6846957-B2
优先权日:2002-11-22
标题 :Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
发明人：ZELENIN ALEXANDER
权利人:UNIV TEXAS
摘要:The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of 1-phenyl-3-methylamino-2-propen-1-one with sodium borohydride and acetic acid.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-12337036-B2
优先权日:2018-01-01
标题:Compounds and methods for trans-membrane delivery of molecules
发明人：ZIV ILAN; GRIMBERG HAGIT; DUBROVSKY JOSEPH
权利人:APOSENSE LTD
摘要:The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.

专利号:US-9056887-B2
优先权日:2011-07-26
标 题 :Minor groove binder phosphoramidites and methods of use
发明人：VOROBIEV ALEXEI; LUKHTANOV EUGENY A
权利人:VOROBIEV ALEXEI; LUKHTANOV EUGENY A; ELITECH HOLDING BV
摘要:Minor groove binder phosphoramidites having the formula M-L-PA, wherein M is a minor groove binder comprising a protected heteroaromatic amine, L is a linker, and PA is a phosphoramidite group, have been synthesized. Preferred methods of synthesis include synthesizing a minor groove binder intermediate containing a transiently protected hydroxyl group, protecting heteroaromatic amines of the corresponding minor groove binder intermediate as carbamate intermediates, reacting the carbamate intermediate to remove the transient protecting group to yield carbamate-protected minor groove binder agent as an intermediate with a free hydroxyl group, and converting the intermediate with a free hydroxyl group to the desired minor groove binder phosphoramidite. These minor groove binder phosphoramidites are useful in the preparation of oligonucleotide conjugates, particularly those for use as probes and primers. In preferred methods, an oligonucleotide sequence is synthesized using nucleoside phosphoramidites and the minor groove binder phosphoramidite is incorporated into the oligonucleotide sequence to form a protected oligonucleotide-minor groove binder conjugate. Then, deprotection produces the oligonucleotide-minor groove binder.

专利号:DE-60302664-T2
优先权日:2002-06-12
标题:SYNTHESIS OF SILICOALUMOPHOSPHATES

专利号:US-2007043234-A1
优先权日:2003-07-09
标 题 :Use of functionalized onium salts as a soluble support for organic synthesis