CAS: 56222-08-3; N-Methyl-1-(2-Nitrophenyl)Methanamine

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CAS号57707-11-6 N-(2-nitrobenzy... | CAS号74-89-5 氨基甲烷 | CAS号612-23-7 邻硝基苄氯 | CAS号552-89-6 邻硝基苯甲醛 | CAS号612-25-9 2-硝基苯甲醇 | CAS号3958-60-9 2-硝基溴苄 | CAS号593-51-1 一甲胺盐酸盐 | CAS号619-23-8 间硝基氯化苄 | CAS号88-72-2 邻硝基甲苯 | CAS号24526-64-5 诺米芬辛 | CAS号1904-69-4 2-氨基-n-甲基苯甲胺 | CAS号65514-97-8 2-[(2-aminophen... | CAS号89543-62-4 2-methyl-4-(4-m... | CAS号4838-00-0 2-甲基-2H-吲唑

N-(2-硝基苯亚甲基)甲胺置于sodium Tetrahydroborate体系中,用 甲醇,水 作为反应溶剂,化学反应 1.0H,以3.60 G的收率获得产物n-甲基-2-硝基苄胺
参考文献:高度立体选择性的friedel-crafts型环化反应.容易获得对映纯的1,4-二氢-4-苯基异喹啉酮
标题:高度立体选择性的friedel-crafts型环化反应.容易获得对映纯的1,4-二氢-4-苯基异喹啉酮
摘要:本报告介绍了基于立体选择性friedel-Crafts型环化反应的1,4-二氢-4-苯基异喹啉酮5的立体选择性合成.环化前体1由易于获得的(S)-扁桃酸分两步制备,总收率为60-80%.立体选择性亲电环化以20-86%的收率和20-97%的ee完成.在这项工作的过程中,发现酰胺羰基的存在对于确保亲电芳族取代过程中的立体定向过程特别重要.
DOI:10.1016/s0040-4020(03)01236-5

专利信息

专利号:US-7718598-B1
优先权日:1998-09-25
标 题:Auxiliary for amide bond formation
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programmes. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganizing peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:CN-1003013-B
优先权日:1986-12-29
标 题 :Synthesis of Nitroacetophenone Hydrochloride, an Intermediate of Antidepressant Nomifensine