CAS: 6872-06-6; 2-Methylindoline

上下游产品

CAS号95-20-5 2-甲基吲哚 | CAS号2058-74-4 1-甲基靛红 | CAS号32704-22-6 2-prop-2-enylaniline | CAS号589-09-3 烯丙基苯胺 | CAS号496-15-1 二氢吲哚 | CAS号2861-59-8 1-甲酸基吲哚啉 | CAS号81763-93-1 N-tert-butyl-1-... | CAS号31529-46-1 1-氨基-2-甲基吲哚啉 | CAS号95-20-5 2-甲基吲哚 | CAS号53406-41-0 2-methylindol-1... | CAS号91-22-5 喹啉 | CAS号75-83-2 2,2-二甲基丁烷 | CAS号841275-78-3 1-Acetyl-2-meth... | CAS号126535-38-4 1H-Indole-1-car... | CAS号1013-18-9 1-(氯乙酰基)-2-甲基吲哚啉 | CAS号1075-34-9 2-甲基-5-溴吲哚 | CAS号1821-39-2 2-丙基苯胺

Tert-Butyl-[1-(2,3-Dihydro-Indol-1-yl)-Meth-(E)-Ylidene]-Amine置于氢氧化钾,叔丁基锂体系中,用 二甲基亚砜 作为反应溶剂,化学反应 3.5H,反应生成 2-甲基吲哚啉
参考文献:偶极稳定的α-氨基碳负离子.三,二氢吲哚,四氢喹啉和正甲基苯胺的金属化烷基化.
标题:偶极稳定的α-氨基碳负离子.三,二氢吲哚,四氢喹啉和正甲基苯胺的金属化烷基化.
摘要:在二氢吲哚和四氢喹啉中的2-位金属化可通过使用-丁基锂的它们的fomamidine衍生物来实现.n-甲基苯胺中的n-甲基也使用该碱金属化.
DOI:10.1016/s0040-4039(01)92435-9

专利信息

专利号:EP-4559899-A1
优先权日:2023-11-21
标 题:Synthesis of 1-amino-2-methyl-2,3-dihydroindole by nitrosating 2-methyl-2,3-dihydro-1h-indole and then reducing the obtained 1-nitroso-2-methyl-2,3-dihydroindole with thiourea dioxide
发明人：GORENC ANA; KRALJ DAVID
权利人:KRKA D D NOVO MESTO
摘要:A process for the synthesis of 1-amino-2-methyl-2,3-dihydroindole 3 or an acid addition salt thereof comprising the steps:(a) providing 2-methyl-2,3-dihydro-1H-indole 1(b) nitrosating the 2-methyl-2,3-dihydro-1H-indole 1 with a nitrosation agent to afford 1-nitroso-2-methyl-2,3-dihydroindole 2(c) reducing the 1-nitroso-2-methyl-2,3-dihydroindole 2 with thiourea dioxide as reducing agent to afford the 1-amino-2-methyl-2,3-dihydroindole 3and(d) optionally, converting the 1-amino-2-methyl-2,3-dihydroindole 3 into the acid addition salt thereof.1-amino-2-methyl-2,3-dihydroindole is a key intermediate in the industrial synthesis of indapamide.

专利号:WO-2023112055-A1
优先权日:2021-12-15
标 题 :New synthetic process design for the synthesis of carboxy tormifene and purity analysis to strengthen antidoping testing
发明人：KUMAR GANGASANI JAGADEESH; PAWAR SACHIN DATTRAM; RADHAKRISHNANAND PULLAPANTHULA; MURTY UPADHYAYULA SURYANARAYANA; SAHU PURAN LAL; DUBEY SACHIN; SAHU KAPENDRA; UPADHYAY AWANISH; KUMAR PRAMOD
权利人:DIRECTOR NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RES GUWAHATI NIPER G; DIRECTOR NAT DOPE TESTING LABORATORY NDTL
摘要:The present invention relates to a process for preparing a compound of formula I: I. The compound of formula I is useful in anti-doping tests.

专利号:US-2012095211-A1
优先权日:2010-09-22
标 题 :Substituted proline inhibitors of hepatitis c virus replication
发明人：BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D
权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC
摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

专利号:US-6222071-B1
优先权日:1997-09-30
标 题 :Synthesis method for solution with high grade chloramine
发明人：DELALU HENRI; PEYROT LAURENT; ELKHATIB MAZEN; COUNIOUX JEAN-JACQUES; COHEN ARMAND
权利人:ADIR ET COMPAGINE
摘要:The present invention relates to a process for the preparation of high-grade chloramine by the action of commercial eau de Javelle of 100 chlorometric degrees on a solution of ammonia in the presence of ammonium chloride. According to this process, the chloramine is obtained having a content greater than or equal to 2 mol L-1, that is to say, greater than or equal to 10.3%. The process can be carried out continuously or discontinuously.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-2006004188-A1
优先权日:2000-09-29
标 题:Intermediates and the synthesis of modified carbocyanine dyes and their conjugates