CAS: 86273-18-9; (5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl (2S,5R,6R)-6-[[(2R)-2-Amino-2-Phenylacetyl]Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
该化合物是一种半合成抗生素,属于青霉素类,主要用于抗菌特性,其特点是能够抑制细菌细胞壁合成,使其对一系列的克抗体和某些克抗菌菌有效. 蓝丙西林经常用于治疗各种感染,包括呼吸道感染,皮肤感染和尿道感染.其化学结构包括一个乙酯环,这是其抗微生物活动必不可少的.该物质通常以盐的形式施用,以提高溶性与生物利用率. 蓝丙西林一般具有良好的耐受性,但与其他抗生素一样,可产生副作用,如过敏反应或胃肠干扰.重要的是,应明智地使用这种抗生素来防止抗生素抗体抗体的发育. 与所有药物一样,其使用应该由保健专业人员指导,考虑到治疗的具体感染和病人的病史等因素.
- 英文名称(5-Methyl-2-Oxo-1,3-Dioxol-4-yl)Methyl (2S,5R,6R)-6-[[(2R)-2-Amino-2-Phenylacetyl]Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
- 中文名称仑氨西林
- IUPAC名称(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (2S,5R,6R)-6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- CAS编号86273-18-9
- MFCD编号:MFCD00865124
- FDA UNII编号:8M568DM08K
- 分子式:C21H23N3O7S
- 分子量:461.49
- 产品CID: 1863896
- 同类组份化合物CAS80734-02-7 (HCl)86273-18-9 (free base)
- 产品分类原料药 → 抗生素类药物 → 青霉素类药
物理性质
- 密度1.47g/cm3
- PSA:170.38
- LogP:1.8606
- 折射率1.653
- 外观形态固体-粉末
- 储存条件2-8°C
- 产品应用该化合物是用于改善口服生物利用率的安匹西林的药剂. 在使用时,它被快速水解成活性安比西林,这显示出对克菌阳性和某些克菌阴性细菌的广谱抗菌活动. 抗乳性谱包括肺炎链球菌(STREPTOCCCUS 肺炎) , 血清球素(非乳酶生产菌株) (STOPHILOCOCCCUCUS AUREUS) , ESCHERICHIRA COLI, 流感嗜血杆菌(HAMOBILUS)和普罗特斯.美比利斯(PROTEUS MIRABILIS) . 释放的安比希林(MIC) 最低抑制浓度值通常介于0.25至8微克/毫升之间,取决于生物体. 伦皮西里宁本身限制直接的抗微生物活性活动,直到新陈代谢化为止,其临床效果镜像像,其顶峰等离子浓度在1-2小时后剂量(250毫克至500毫克)内达到约4-6/毫里.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
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专利信息
专利号:US-6642377-B1
优先权日:1999-07-30
标 题 :Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates
发明人：KAYANO AKIO; CHIBA HIROYUKI; NAKAMURA TAIJU; SAKURAI SHIN; ISHIZUKA HIROYUKI; SAITO HIROYUKI; KOMATSU YUUKI; SASHO MANABU; SATO NOBUAKI; NEGI SHIGETO
权利人:EISAI CO LTD
摘要:A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid:wherein the ring A means the basic antibiotic; R<10 >means a protected functional group used in organic synthesis; Ak-E means the alkali earth metal; and B means the inorganic acid, respectively.
专利号:CN-1261427-C
优先权日:2003-08-18
标 题 :Synthesis of 4,5-dimethyl-1,3-dioxane amylene-2-one
专利号:CN-115353539-B
优先权日:2022-07-13
标题 :Application of oligomeric nucleic acid-tetrahydrothiazole compounds in the synthesis of gene-encoded compound libraries
专利号:CN-115385973-B
优先权日:2022-07-13
标题:Application of oligomeric nucleic acid-tetrahydrothiazole compounds in the synthesis of gene-encoded compound libraries
专利号:CN-116715639-A
优先权日:2023-04-24
标 题 :Synthesis and use of bifunctional molecules targeting HDAC/PD-L1 based on o-phenylenediamine and hydrazides
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河北省石家庄市高新区天山大街266号创新大厦2-710
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主要参考文献
1: Sum ZM, Sefton AM, Jepson AP, Williams JD. Comparative pharmacokinetic study between lenampicillin, bacampicillin and amoxycillin. J Antimicrob Chemother. 1989 Jun;23(6):861-8.
7: Privitera G, Ortisi G, Scarpellini P, Nicastro G, Moro M, Cernuschi M. Impact of lenampicillin on the fecal flora of healthy volunteers. J Chemother. 1989 Jul;1(4 Suppl):600-2. Japanese. Japanese. Japanese. doi: 10.1002/jps.21867. Japanese. Japanese. Japanese. Japanese. Japanese.
合成参考文献
参考文献:10.1007/s101560200012
摘要:Yoshii T, Hamamoto Y, Muraoka S, Furudoi S, Komori T. Differences in postoperative morbidity rates, including infection and dry socket, and differences in the healing process after mandibular third molar surgery in patients receiving 1-day or 3-day prophylaxis with lenampicillin. J Infect Chemother. 2002 Mar;8(1):87–93. doi: 10.1007/s101560200012.
参考文献:10.1007/s101560200022
摘要:Kumazawa J, Yagisawa M. The history of antibiotics: the Japanese story. J Infect Chemother. 2002 Jun;8(2):125–33. doi: 10.1007/s101560200022.
摘要:Sefton AM, Jepson AP, Sun ZM, Williams JD. A comparative pharmacokinetic study between lenampicillin, bacampicillin and amoxycillin. J Chemother. 1989 Jul;1(4 Suppl):494–5.
摘要:Privitera G, Ortisi G, Scarpellini P, Nicastro G, Moro M, Cernuschi M. Impact of lenampicillin on the fecal flora of healthy volunteers. J Chemother. 1989 Jul;1(4 Suppl):600–2.
摘要:Miki F, Soejima R. A review of clinical studies on lenampicillin in Japan. J Chemother. 1989 Jul;1(4 Suppl):640–2.
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