CAS: 889858-12-2; Tert-Butyl 4-Bromo-2-Fluorobenzoate

上下游产品

CAS号151982-51-3 4-溴-2-氟苯甲酰氯 | CAS号75-65-0 叔丁醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号1435-52-5 1,4-二溴-2-氟苯

4-溴-2-氟苯甲酸置于草酰氯体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 24.0H,反应生成 4-溴-2-氟苯甲酸叔丁酯
参考文献:化学工程多孔分子涂层作为活性氧物质发生器和储层,用于长效自清洁纺织品
标题:化学工程多孔分子涂层作为活性氧物质发生器和储层,用于长效自清洁纺织品
摘要:制备了一系列可溶液加工的结晶多孔材料,并将其用作纺织品涂层,在吸收日光后自发地将空气中吸收的氧气转化为活性氧 (Ros),并在黑暗条件下长期储存 Ros.这项工作为进一步开发自清洁纺织品涂层铺平了道路,用于在日光和无光条件下快速灭活高传染性病原菌.
DOI:10.1002/anie.202115956

专利信息

专利号:WO-2015110467-A1
优先权日:2014-01-23
标 题:Process for the preparation of substituted n-(5-benzenesulfonyl-1h-indazol-3-yl)-benzamides
发明人：ARCARI ALESSANDRO; D ARASMO GERMANO; LOMBARDI BORGIA ANDREA
权利人:NERVIANO MEDICAL SCIENCES SRL
摘要:The present invention relates to a process for the preparation of substituted N-(5-benzenesulfonyl-1 H-indazol-3-yl)-benzamides and to the useful intermediate compounds of such process. Such derivatives are described and claimed in WO2008/074749, which also discloses processes for their preparation. The process of the present invention allows to obtain the desired products in high yields and purity and with a limited number of steps. The synthesis starts from 5-iodo-1 H-indazol-3-ylamine and comprises, as the key steps, the coupling of an activated benzoic acid with a 5-phenylsulfanyl-1 H-indazol-3-ylamine scaffold and the subsequent oxidation of the sulfur atom, followed by further functional group transformations, which furnish the desired products. The compounds prepared according to the process of the present invention are endowed with protein kinase inhibiting activity and, more particularly, IGF-1R or ALK inhibiting activity. The compounds are therefore useful in the treatment of a variety of cancers, cell proliferative disorders and diseases associated with protein kinases.