CAS: 944401-58-5; 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-4-(Trifluoromethyl)Pyrimidin-2-Amine

该化合物是一种广泛用于铃木-米亚乌拉交叉相交反应的丙酰丙胺催化物衍生物,其存在可增强有机溶剂的稳定性和溶性,促进与卤化物的有效结合.三氟二甲基代基元素传递电子提取特性,影响合成应用中的再活动性和选择性.该化合物在制药和农用化学研究中特别有用,是建立复杂多环化框架的关键中间体.其高纯度和完善的结构确保了混合反应的再现性,从而成为先进的有机合成的可靠选择.

英文名称5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-4-(Trifluoromethyl)Pyrimidin-2-Amine
中文名称2-氨基-4-三氟甲基嘧啶-5-硼酸频哪醇酯
IUPAC名称5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine
其它别名2-氨基-4-三氟甲基嘧啶-5-硼酸频哪醇酯; 2-氨基-4-三氟嘧啶-5-硼酸频哪醇酯; 2-Amino-4-Trifluoropyrimidine-5-Boronic Acid Pinacol Ester
CAS编号944401-58-5
MFCD编号:MFCD09952051
分子式:C11H15BF3N3O2
分子量:289.07
产品CID: 1994916
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: FEVSQCNVVXXUBK-UHFFFAOYSA-N
InChI=1S/C11H15BF3N3O2/c1-9(2)10(3,4)20-12(19-9)6-5-17-8(16)18-7(6)11(13,14)15/h5H,1-4H3,(H2,16,17,18)…
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数1.0

相似化合物

2417014-06-1 944401-55-2 2377611-40-8

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

上下游产品

CAS号935534-47-7 4-三氟甲基-5-溴-2-嘧啶胺 | CAS号73183-34-3 双戊酰二硼 | CAS号16075-42-6 2-氨基-4-(三氟甲基)嘧啶

合成工艺路线路线简述

73183-34-3 + 935534-47-7 = 944401-58-5
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; 4 H,115 °C; 115 °C -> 50 °C1.2 Reagents: Ethyl Acetate
标题:2-Oxooxazolidinylpyrimidine Derivatives As Pi3K Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

73183-34-3 + 935534-47-7 = 944401-58-5
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 4 H,115 °C; 115 °C -> 50 °C
标题:One-Step Synthesis Of 3,4-Disubstituted 2-Oxazolidinones By Base-Catalyzed Co2 Fixation And Aza-Michael Addition
作者:Mannisto,Jere K.; Sahari,Aleksi; Lagerblom,Kalle; Niemi,Teemu; Nieger,Martin; Et Al
参考文献:Chemistry - A European Journal 日期:2019 卷标:25(44) 页码:10284-10289]

73183-34-3 + 935534-47-7 = 944401-58-5
反应条件:1.1 Reagents: Potassium Acetate Solvents: 1,4-Dioxane; 15 Min,Rt1.2 Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium; 6 H,115 °C; 115 °C -> Rt
标题:Pyrimidine Derivatives Used As Pi-3 Kinase Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
参考文献:World Intellectual Property Organization]

= 944401-58-5 [标题:Reaction Conditions
标题:Pi 3-Kinase Inhibitors And Methods Of Their Use
参考文献:United States]

73183-34-3 + 935534-47-7 = 944401-58-5 + 16075-42-6
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 2 H,120 °C
标题:Mechanistic Target Of Rapamycin Signaling Pathway Inhibitors,Therapeutic Applications,And Preparation
参考文献:World Intellectual Property Organization]

73183-34-3 + 935534-47-7 = 944401-58-5 + 16075-42-6
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; 6 H,115 °C
标题:Identification Of Nvp-Bkm120 As A Potent,Selective,Orally Bioavailable Class I Pi3 Kinase Inhibitor For Treating Cancer
作者:Burger,Matthew T.; Pecchi,Sabina; Wagman,Allan; Ni,Zhi-Jie; Knapp,Mark; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2011 卷标:2(10) 页码:774-779]

73183-34-3 + 935534-47-7 = 944401-58-5
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; 4 H,115 °C
标题:Preparation Of Oxazolidin-2-One Compounds And Uses Thereof As Pi3K Inhibitors
参考文献:World Intellectual Property Organization]

73183-34-3 + 935534-47-7 = 944401-58-5
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; Overnight,115 °C; 115 °C -> Rt1.2 Reagents: Water Solvents: Ethyl Acetate
标题:Preparation Of 2-Morpholino-4,6-Disubstituted Pyrimidine Analogues And Their Application As Anticancer Agents
参考文献:World Intellectual Property Organization]

73183-34-3 + 935534-47-7 = 944401-58-5
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 6 H,115 °C
标题:Preparation Of Dimorpholinopyrimidines For Inhibiting Hamartoma Tumor Cells
参考文献:World Intellectual Property Organization]

73183-34-3 + 935534-47-7 = 944401-58-5
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 6 H,115 °C; 115 °C -> Rt
标题:Preparation Of Imidazo[1,2-A]Pyridines And Imidazo[1,2-B]Pyridazines As Pi-3 Kinase Inhibitors
参考文献:World Intellectual Property Organization]

= 944401-58-5 [标题:Reaction Conditions
标题:Method Of Inhibiting Hamartoma Tumor Cells
参考文献:United States]

73183-34-3 + 935534-47-7 = 944401-58-5 + 1045861-30-0
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; 6 H,115 °C; 115 °C -> Rt
标题:Pyridine Derivatives As Pi3K Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Diseases
参考文献:World Intellectual Property Organization

4-三氟甲基-2-氨基嘧啶置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,N-溴代丁二酰亚胺(Nbs),Potassium Acetate体系中,用 1,4-二氧六环,二氯甲烷作为反应溶剂,化学反应 50.0H,反应生成 2-氨基-4-三氟嘧啶-5-硼酸频哪醇酯
参考文献: Mechanistic Target Of Rapamycin Signaling Pathway Inhibitors And Therapeutic Applications Thereof[fr] Cible Mécaniste D'Inhibiteurs De La Voie De Signalisation De La Rapamycine Et Ses Applications Thérapeutiques
标题: Mechanistic Target Of Rapamycin Signaling Pathway Inhibitors And Therapeutic Applications Thereof[fr] Cible Mécaniste D'Inhibiteurs De La Voie De Signalisation De La Rapamycine Et Ses Applications Thérapeutiques
摘要:公式(I)-(Iii)的选择性mtor抑制剂,其制备方法,含有它们的药物组合物,以及它们在治疗由mtor激酶和/或一个或多个pi3K酶介导的异常细胞生长,功能或行为引起的疾病和紊乱中的用途.这些疾病和紊乱包括癌症,免疫紊乱,心血管疾病,病毒感染,炎症,代谢/内分泌功能紊乱和神经系统紊乱.