专利号:US-10040752-B2 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof 发明人:MKRTCHYAN GNEL; YAO QINGWEI 权利人:CODY LABORATORIES INC 摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.
专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-4939112-A 优先权日:1988-10-06 标 题:Catalyst for synthesis of vesicular phenoxy resins 发明人:BENNETT EVERETT W 权利人:JAMES RIVER PAPER CO 摘要:A catalyst for synthesis of vesicular phenoxy resins is disclosed. The catalyst includes a water-insoluble complex of a hydric phenol and a quaternary ammonium or phosphonium salt of the hydric phenol. Preferably, the hydric phenol is an intermediate of the phenoxy resin being produced. Dihydric phenols, such as sulfonyldiphenol are preferred. The invention further relates to a reaction medium for polymerization of phenoxy resins including the above-described catalyst and a solvent medium capable of dissolving the phenoxy resins and otherwise not interfering with the polymerization reaction. The solvent medium is advantageously free of toxic Methyl Cellosolve.
专利号:US-7767826-B2 优先权日:2007-10-05 标题 :Process for the synthesis of L-(+)-ergothioneine 发明人:TRAMPOTA MIROSLAV 权利人:PHARMATECH INTERNATIONAL INC 摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.
专利号:US-4092351-A 优先权日:1976-02-17 标 题 :Method of synthesis of 4,5,6-trihydroxyisophthalic acid 发明人:SHIPCHANDLER MOHAMMED T 权利人:IMC CHEMICAL GROUP 摘要:A process for the synthesis of 4,5,6-trihydroxyisophthalic acid by reacting dialkyl glutarate with dialkyl dialkoxymalonate.
专利号:US-4046817-A 优先权日:1974-07-19 标题 :Method of synthesis of pyrogallol 发明人:SHIPCHANDLER MOHAMMED T 权利人:IMC CHEMICAL GROUP 摘要:A process for the synthesis of pyrogallol from glutaric ester and dialkoxymalonic ester.
1: Aizawa A, Ito A, Masui Y, Sasaki K, Ishimura Y, Numata M, Abe R. A case of allergic contact dermatitis caused by goalkeeper gloves. Contact Dermatitis. 2018 Apr 30. doi: 10.1111/cod.13011. [Epub ahead of print] doi: 10.1016/j.chemosphere.2018.03.185. Epub 2018 Mar 29. doi: 10.1016/j.jcis.2017.12.042. Epub 2017 Dec 16. doi: 10.1111/cod.12824. doi: 10.1002/tox.22461. Epub 2017 Aug 24. doi: 10.1155/2017/3102358. Epub 2017 Mar 15. 7: Liu R, Lin Y, Ruan T, Jiang G. Occurrence of synthetic phenolic antioxidants and transformation products in urban and rural indoor dust. Environ Pollut. 2017 Feb;221:227-233. doi: 10.1016/j.envpol.2016.11.069. doi: 10.1016/j.scitotenv.2016.10.232. Epub 2016 Nov 9. doi: 10.1007/s11356-016-8032-z. Epub 2016 Nov 9. doi: 10.1111/ijd.13384. Epub 2016 Aug 6. doi: 10.1016/j.ecoenv.2016.09.035. Epub 2016 Oct 7. doi: 10.1016/j.scitotenv.2016.05.064. Epub 2016 May 20. doi: 10.1111/pde.12836. Epub 2016 Apr 13. Review. Japanese. doi: 10.1080/10934529.2015.1120541. Epub 2016 Jan 28. doi: 10.1016/j.chroma.2015.11.003. Epub 2015 Nov 10. doi: 10.1111/cod.12492. Epub 2015 Nov 5. doi: 10.1111/bjd.14167. Epub 2015 Dec 26. doi: 10.1021/acs.inorgchem.5b01297. Epub 2015 Aug 24. doi: 10.1111/cod.12401. Epub 2015 Apr 23.
合成参考文献
参考文献:10.1021/jo200927v 摘要:Bew SP, Sharma SV. Do commercially available metal salts mediate calixarene formation via hydrogen-bonded dimers J Org Chem. 2011 Sep 02;76(17):7076–83. doi: 10.1021/jo200927v.