CAS: 123-56-8; Pyrrolidine-2,5-Dione

相似化合物

2142-06-5 1121-07-9 128-08-5

上下游产品

CAS号872-50-4 N-甲基吡咯烷酮(NMP) | CAS号617-45-8 DL-天门冬氨酸 | CAS号56-84-8 L-天门冬氨酸 | CAS号67-56-1 甲醇 | CAS号638-32-4 琥珀酰胺酸 | CAS号108-30-5 丁二酸酐 | CAS号6310-19-6 4-(叔丁基)-2-硝基苯胺 | CAS号70289-38-2 4-氯-1-[4-(1-甲基乙... | CAS号2226-88-2 丁二酸铵 | CAS号4553-62-2 2-甲基戊二腈 | CAS号74-89-5 氨基甲烷 | CAS号10478-33-8 N-(2-丙炔基)琥珀酰亚胺 | CAS号38862-24-7 N-羟基琥珀酰亚胺丙烯酸酯 | CAS号4146-43-4 丁二酸二酰肼 | CAS号5335-87-5 4,4'-二甲氧基二苯二硫醚 | CAS号5724-76-5 3-(2,5二氧-吡咯啉-1-基)-丙酸 | CAS号32703-87-0 B°C-L-丙氨酸N-丁二酸酰亚胺 | CAS号14181-05-6 1-Pyrrolidineac... | CAS号14565-47-0 2,5-二氧代吡咯烷-1-基十二酸酯

丁二酸酐置于4-二甲氨基吡啶,盐酸羟胺体系中,化学反应 0.03H,以96%的收率获得丁二酰亚胺
参考文献:The Synthesis Of Unsubstituted Cyclic Imides Using Hydroxylamine Under Microwave Irradiation
标题:The Synthesis Of Unsubstituted Cyclic Imides Using Hydroxylamine Under Microwave Irradiation
摘要:未取代的环状亚胺通过一系列环状酐,盐酸羟胺(Nh2Oh.hcl)以及4-N,N-二甲氨基吡啶(Dmap,碱催化剂)在单模和多模微波辐照下合成.这种新颖的微波合成方法在单模微波(产率61%-81%)和多模微波(产率84%-97%)条件下均能产生高产量的未取代环状亚胺.
Doi:10.3390/molecules13010157

专利信息

专利号:US-9446995-B2
优先权日:2012-05-21
标 题:Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
发明人：CHONG HYUN-SOON
权利人:CHONG HYUN-SOON; ILLINOIS INST OF TECH
摘要:Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人：YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:US-9884885-B2
优先权日:2009-05-18
标题:Synthesis of labile base protected-modified deoxy and modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting group, which is significantly faster base labile protecting group, yet significantly more stable than commonly utilized-2-isobutyryl guanosine is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups, including acetyl group from guanine and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of acetyl protecting groups of the natural deoxy and ribonucleosides occurs under substantially reduced time in contact with mild deprotection conditions such as mild bases, secondary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is designed to lead to high purity large scale therapeutic grade oligonucleotide chimeras which consist of fluoro sugar modification in conjunction with deoxy nucleosides, ribonucleosides, modified base and modified sugar nucleosides. This approach is further designed to use acetyl guanine protecting group when other bases are sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides.

专利号:US-8981076-B2
优先权日:2008-11-29
标 题 :Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:This invention relates to synthesis of novel -N-FMOC protected nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-FMOC as nucleoside base protecting group, which is highly base labile protecting group is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of FMOC protecting groups of the natural deoxy and ribonucleosides occurs under very mild deprotection conditions such as mild bases, secondary and tertiary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is further designed to use FMOC protecting group on various base sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides. DNA oligonucleotides containing 3′-end dA at the 3′-terminal will be produced using the FMOC-dA-supports would lead to much reduced M−1 deletion sequences, and thereby high purity.

专利号:US-10364220-B2
优先权日:2012-12-21
标题:Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves
发明人：SCHMITT KIRK D; ZUSHMA STEPHEN; BURTON ALLEN W
权利人:EXXONMOBIL CHEMICAL PATENTS INC
摘要:The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.

专利号:US-9090560-B2
优先权日:2013-09-04
标 题 :Process for microwave assisted synthesis of N-methyl pyrrolidone
发明人：KHATRI PRAVEEN KUMAR; JAIN SUMAN LATA; CHATERJEE ALOK KUMAR; BIR SAIN
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for microwave assisted synthesis of N-methyl pyrrolidone (NMP). Particularly the process relates to the synthesis of N-methyl succinimide or corresponding analogs by using microwave irradiation which on hydrogenation in the presence of a hydrogenating catalyst gives N-methyl pyrrolidone. Compared to the conventional heating microwave process requires less energy inputs and reduces the reaction time drastically from 5-6 h to 2-5 min.