CAS: 177947-96-5; Tert-Butyl 3-Formylazetidine-1-Carboxylate

相似化合物

1638761-59-7 142253-55-2 142253-56-3

上下游产品

3-hydroxymethyl-azetidine-1-carboxylic acid tert-butyl ester tert-butyl dicarbonatedi-tert-butyl dicarbonate 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid carbon monoxide 3-((E)-2-ethoxycarbonylvinyl)azetidine-1-carboxylic acid tert-butyl ester 3-((E)-2-carboxyvinyl)azetidine-1-carboxylic acid tert-butyl ester 3-((E)-2-(methyl((1R)-1-(methyl((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)vinyl)azetidine-1-carboxylic acid tert-butyl ester 3-[4-(3-acetylaminophenyl)piperidin-1-ylmethyl]azetidine-1-carboxylic acid tert-butyl ester

3-羟甲基氮杂环丁烷-1-羧酸叔丁酯置于草酰氯,三乙胺体系中,用 二氯甲烷,二甲基亚砜 用作溶剂,以65 %的收率获得3-甲酰基氮杂环丁烷-1-羧酸叔丁酯
参考文献:氟化脂肪二氮杂环丙烷:制备,表征和模型光标记研究
标题:氟化脂肪二氮杂环丙烷:制备,表征和模型光标记研究
摘要:合成并表征了以前未知的二氟甲基二氮杂环丙烷和以前被忽视的三氟甲基-脂肪族二氮杂环丙烷.模型光标记实验和生物学研究表明,这些化合物确实可以用作光亲和标记.
Doi:10.1021/acs.Joc.2C02262

专利信息

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-2013060019-A1
优先权日:2011-09-07
标 题 :Compounds for Use in Treating Neurodegenerative Disorders, Synthesis Thereof, and Intermediates Thereto
发明人：BRONK BRIAN SCOTT; AUSTIN WESLEY FRANCIS; CREASER STEFFEN PHILLIP; FULLER NATHAN OLIVER; HUBBS JED LEE; SHEN RUICHAO
权利人:BRONK BRIAN SCOTT; AUSTIN WESLEY FRANCIS; CREASER STEFFEN PHILLIP; FULLER NATHAN OLIVER; HUBBS JED LEE; SHEN RUICHAO; SATORI PHARMACEUTICALS INC
摘要:The present invention provides methods of making a compound of formula II: n n n n n n n n n n or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , and L are as defined and described herein.

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis

专利号:EP-3083583-B1
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof