专利号:US-5750764-A 优先权日:1995-11-17 标题 :Synthesis and resolution of propionic acid derivatives 发明人:MARAIS STEPHANUS FRANCOIS; KHAILE THEBEEAPELO JOHN; NJAMELA OWEN LUNGILE; BRAITHWAITE DANA HELEN; DAVIDSON DEBORAH NICOLE; JUNGMANN CHRISTA MARIA; PARKINSON CHRISTOPHER JOHN; GARDINER NEIL STOCKENSTROM; STEENKAMP LUCIA HENDRINA; VAN EEDEN SKEIN ETIENNE 权利人:AECI LTD 摘要:A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of α-arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.
专利号:US-10377699-B2 优先权日:2013-11-06 标 题 :Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue 发明人:LI XUECHEN; LAM HIU YUNG 权利人:UNIV HONG KONG 摘要:A method for the synthesis of daptomycin or a daptomycin analog is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogs can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogs can include a different fatty acid in the side arm of the daptomycin analog.
专利号:US-8258362-B2 优先权日:2009-05-04 标 题:Method for the production of α, ω-olefins by using the copper catalyzed coupling reaction of a Grignard reagent with an allylic substrate 发明人:NACHARAJU KRISHNAMURTHY; TAYLOR PAUL D; COONEY MARK J; CRABTREE LARRY A 权利人:NACHARAJU KRISHNAMURTHY; TAYLOR PAUL D; COONEY MARK J; CRABTREE LARRY A; ISP INVESTMENTS INC 摘要:A process for the synthesis of linear α,ω-diolefins from an allylic substrate comprises the steps of a) forming the bis-Grignard reagent XMgCH2(CH2)nCH2MgX from an α,ω-acyclic dihalide with X being a halogen; b) preparing a solution comprising an allylic substrate and a copper catalyst; c) catalyzing a coupling reaction by adding to the solution of step (b) the bis-Grignard reagent of step (a); and d) isolating and purifying the α,ω-olefin coupling reaction product.
专利号:US-2023312827-A1 优先权日:2022-04-04 标 题 :Synthesis of novel poly(ester urea)s for drug delivery 发明人:OLSEN BRADLEY D; SUREKA HURSH VARDHAN; FRANSEN KATHARINA 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are poly(ester urea)s containing two or more units containing two amino acid monomers linked by a linker. At least two units of the poly(ester urea)s are covalently bonded via a urea bond. Suitable amino acid monomers are lysine, arginine, aspartic acid, phenylalanine, or a side chain protected derivative thereof, and suitable linkers are selected from a 1,4-butane diol group, a 1,6-hexane diol group, diethylene glycol group, a triethylene glycol group, or an N-methyl diethanolamine group. The poly(ester urea)s are used to form polyplexes for the improved complexation and delivery of drugs to a subject in need thereof.
专利号:US-2024067674-A1 优先权日:2020-12-28 标 题 :Method for loading amino acid on resin for solid-phase synthesis 发明人:SEKITA HIROKO; KOMIYA SHIO; DAN KATSUNORI 权利人:CHUGAI PHARMACEUTICAL CO LTD 摘要:An object of the present invention is to provide a method for efficiently producing a peptide compound of high purity at a high yield. It was found that an amino acid can be efficiently loaded on a resin for solid-phase synthesis by bringing an amino acid solution containing a specific solvent into contact with a resin for solid-phase synthesis that has been swollen with a specific solvent, thereby solving such problem.
专利号:US-4270015-A 优先权日:1979-02-05 标题:Manufacture of ethylene from synthesis gas (D#75,673-C1) 发明人:KNIFTON JOHN F 权利人:TEXACO INC 摘要:This invention concerns a two-step process for the preparation of ethylene from mixture of carbon monoxide and hydrogen (commonly known as synthesis gas) by reaction of said carbon monoxide/hydrogen mixtures with a carboxylic acid in the presence of one or more ruthenium catalyst complexes to form an ethyl ester of said carboxylic acid coreactant, followed by pyrolysis of said ethyl ester intermediate to ethylene.
参考文献:10.1021/jo902697g 摘要:Bechem B, Patman RL, Hashmi AS, Krische MJ. Enantioselective carbonyl allylation, crotylation, and tert-prenylation of furan methanols and furfurals via iridium-catalyzed transfer hydrogenation. J Org Chem. 2010 Mar 05;75(5):1795–8.