CAS: 261723-33-5; (2-Bromo-6-Fluorophenyl)Methanol

上下游产品

2-bromo-6-fluorobenzoic acid 2-bromo-6-fluorobenzaldehyde 2-bromo-6-fluoro-1-(methoxymethoxymethyl)benzene 1,3-Dihydro-4-fluoro-1-hydroxy-2,1-benzoxaborole 1-bromo-2-(bromomethyl)-3-fluorobenzene 1-bromo-2-(chloromethyl)-3-fluorobenzene

2-溴-6-氟苯甲醛置于甲醇,Sodium Tetrahydroborate体系中,化学反应生成2-溴-6-氟苯甲醇
参考文献:中断束缚双烯酮的科里-柴可夫斯基反应以获得 2,3-环氧-六氢芴-9-酮
标题:中断束缚双烯酮的科里-柴可夫斯基反应以获得 2,3-环氧-六氢芴-9-酮
摘要:Corey-Chaykovsky 反应通常用于从活化烯烃合成环丙烷.我们截取了这一转化过程中盛行的中间体,并改变了创建复杂分子基序的过程.我们描述了通过"中断的科里-柴可夫斯基反应"将束缚双烯酮转化为 2,3-环氧-六氢芴-9-酮的不寻常的骨架重塑.该策略合理地将硫叶立德的亲核特性与电子偏压烯烃相结合,以实现几种新型氢芴酮的区域和立体选择性合成.我们已经证明了该产品在获得几种高度功能化分子方面的合成效用.
Doi:10.1021/acs.Orglett.4C01550

专利信息

专利号:US-8338451-B2
优先权日:2008-03-21
标 题 :Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO; SANOFI SA
摘要:Compounds of formula (I): n nwherein R, R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:US-8148370-B2
优先权日:2008-03-21
标题 :Polysubstituted derivatives of 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; SANOFI AVENTIS
摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.