CAS: 42854-62-6; L-Alanine Benzyl Ester P-Toluenesulfonate Salt

该化合物是L-alaine的一种受保护衍生物,其中碳酸盐组用苯乙烯醇进行酯化,并稳定为聚苯乙烯酸盐,该化合物广泛用于peptide合成,特别是固相和溶解阶段方法,因为它有能力保护氨酸的碳化物功能,同时可以让矿物质组进一步混合反应. 聚乙烯对流可以提高有机溶剂的溶解性,便利净化和处理. 其晶体形式可以保证高纯度和稳定性,成为制药和生物化学研究中精确合成应用的可靠试剂.

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CAS号56-41-7 L-丙氨酸 | CAS号104-15-4 对甲苯磺酸 | CAS号100-51-6 苯甲醇 | CAS号82717-96-2 N-[1-(S)-乙氧羰基-3... | CAS号17664-94-7 N-苄氧羰基-L-亮氨酰-L-丙氨酸苯酯 | CAS号6510-99-2 2-[[4,5-bis(4-m... | CAS号52616-95-2 tert-butyl 2-(1...

合成工艺路线路线简述

    对甲苯磺酸,Alkaline Earth Salt Of/the/ Methylsulfuric Acid 以 四氢呋喃 作为反应溶剂,化学反应 2.0H,以88%的收率获得产物l-丙氨酸苄酯对甲苯磺酸盐
    参考文献:Barlos,Kleomenis; Gatos,Dimitrios; Kallitsis,Ioannis,Liebigs Annalen Der Chemie,1988,P. 1079-1082
    标题:Barlos,Kleomenis; Gatos,Dimitrios; Kallitsis,Ioannis,Liebigs Annalen Der Chemie,1988,P. 1079-1082

    海关参考信息

    专利信息


    专利号:US-4515920-A
    优先权日:1984-04-30
    标题 :Synthesis of peptides and proteins
    发明人:ERICKSON BRUCE W
    权利人:UNIV ROCKEFELLER
    摘要:Solid phase synthesis of peptides and proteins have been improved by the use of a trifunctional segment, one functional group of which is bound to a solid support, the other two functional groups being available as substrates upon which identical proteins are synthesized.

    专利号:US-4517119-A
    优先权日:1983-04-04
    标题:Synthesis of thymosin α1
    发明人:FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
    权利人:HOFFMANN LA ROCHE
    摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.

    专利号:EP-0149582-B1
    优先权日:1984-01-19
    标 题 :Process for the preparation of aspartyl peptides and derivatives of aspartic acid useful in their synthesis

    专利号:US-6858585-B1
    优先权日:1996-06-25
    标题 :Cyclic depsipeptides and drugs containing the same as the active ingredient
    发明人:YANAI MAKOTO; SUZUKI MASASHI; OSHIDA NORIO; KAWAMURA KOJI; HIRAMOTO SHIGERU; YASUDA ORIE; KINOSHITA NOBUHIRO; SHINGAI AKIKO; TAKASU MASAKO
    权利人:NISSHIN SEIFUN GROUP INC
    摘要:Cyclic depsipeptides represented by the formula n n nwherein:n n R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.

    专利号:CN-102241674-A
    优先权日:2010-05-12
    标题 :Synthesis and Antitumor Activity Evaluation of 1,1-Dimethyl-β-carboline-3-formyl Amino Acid Benzyl Ester

    专利号:SU-1705303-A1
    优先权日:1987-09-01
    标 题 :Method of glycopeptides synthesis
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    合成参考文献

    合成方法参考DOI号:10.1039/c1ob06074k
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