CAS: 444-30-4; 2-(Trifluoromethyl)Phenol

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CAS号392-83-6 邻溴三氟甲苯 | CAS号89466-08-0 2-羟基苯硼酸 | CAS号129946-88-9 S-(三氟甲基)二苯并噻吩三氟甲基磺酸盐 | CAS号444-29-1 2-碘三氟甲苯 | CAS号95-56-7 2-溴苯酚 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号395-47-1 (2-(trifluorome... | CAS号384-22-5 2-硝基-Alpha,Alph... | CAS号351-36-0 3-乙酰氨基三氟甲苯 | CAS号393-11-3 4-硝基-3-三氟甲基苯胺 | CAS号336628-67-2 3-(三氟甲基)水杨醛 | CAS号3411-95-8 2-(2-羟苯基)苯并噻唑 | CAS号395-48-2 2-(三氟甲基)苯甲醚 | CAS号50824-04-9 4-溴-2-三氟甲基苯酚 | CAS号149209-48-3 2-碘-6-(三氟甲基)苯酚 | CAS号921605-76-7 N-叔丁氧羰基-4-(2-三氟... | CAS号791-28-6 三苯基氧化膦 | CAS号20237-92-7 2-(4,5-二氢恶唑-2-基)苯酚 | CAS号199188-29-9 2-(TRIFLUOROMET... | CAS号251300-32-0 2-羟基-3-(三氟甲基)苯甲酸

邻溴三氟甲苯置于cesiumhydroxide Monohydrate,(1,5-环辛二烯)二(三甲基硅烷基甲基)钯(II),2-((Di-Adamantan-1-yl)Phosphaneyl)-1-(2,6-Diisopropylphenyl)-1H-Imidazole体系中,用 四氢呋喃 作为反应溶剂,化学反应 20.0H,以67%的收率获得产物邻三氟甲基苯酚
参考文献:室温下钯催化芳基卤化物的羟基化
标题:室温下钯催化芳基卤化物的羟基化
摘要:降低热量:介绍了第一种室温下pd催化的由芳基溴化物和氯化物合成苯酚的方法.使用笨重的咪唑基膦配体和新型钯前体[pd(cod)(ch 2 Sime 3)2]进行的钯介导的芳基卤化物羟基化反应的化学计量研究导致了在环境条件下高效催化合成苯酚的过程(参见方案) ; Ad =金刚烷基,Cod = 1,5-环辛二烯).
DOI:10.1002/anie.200902148

专利信息

专利号:US-6342582-B1
优先权日:1989-12-04
标 题 :Reaction and dissolving medium for peptides and synthesis method using this medium
发明人：GALVEZ MARIE; MAURICE MARIE-FRANCE
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a reaction and dissolving medium for the synthesis of peptides. This reaction and dissolving medium for peptide synthesis and/or purification comprises a diluent A chosen from a group of water-immiscible solvents and a phenol B. By employing this reaction and dissolving medium, peptides can be synthesized which are useful as medicaments, vaccines, agro-foodstuff products or plant protection products.

专利号:US-2015031898-A1
优先权日:2012-03-09
标题 :Process for preparation of prostaglandin f2 alpha analogues
发明人：DAMS IWONA; KUTNER ANDRZEJ; CHODYNSKI MICHAL; KRUPA MALGORZATA; PIETRASZEK ANITA; ZEZULA MARTA; CMOCH PIOTR; KOSINSKA MONIKA
权利人:INST FARMACEUTYCZNY
摘要:A convergent synthesis of the prostaglandin F 2α analogues, travoprost and bimatoprost, was developed employing Julia-Lythgoe olefination of the structurally advanced phenylsulfone with an enantiomerically pure aldehyde ω-chain synthon. The novel convergent strategy allows the synthesis of a whole series of prostaglandin analogues of high purity from a common and structurally advanced prostaglandin intermediate.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2016318862-A1
优先权日:2013-09-25
标 题:Synthesis of delta 12-pgj3 and related compounds
发明人：NICOLAOU KYRIACOS C; HERETSCH PHILIPP; HALE CHRISTOPHER R H; EL GHZAOUI ABDELLATIF EL MARROUNI; PULUKURI KIRAN KUMAR; YU RUOCHENG; GROVE CHARLES
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of Δ 12 -PGJ 3 and modular synthetic pathways to obtaining Δ 12 -PGJ 3 and derivatives thereof. In some aspects, the present derivatives of Δ 12 -PGJ 3 are useful as chemotherapeutic agents. The present disclosure also describes compositions of these derivatives as well as methods of use of the derivatives thereof.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:US-2009118296-A1
优先权日:2005-07-20
标 题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
发明人：BLACK CAMERON; DESCHENES DENIS; GAGNON MARC; LACHANCE NICOLAS; LEBLANC YVES; LEGER SERGE; LI CHUN SING; OBALLA RENATA M
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.