专利号:US-11008298-B2 优先权日:2019-05-24 标 题:Synthesis of 5-hydroxymethylfurfural 发明人:MOSIER NATHAN SCOTT; OVERTON JONATHAN CHRISTOPHER 权利人:PURDUE RESEARCH FOUNDATION 摘要:The present disclosure relates to a novel and improved synthesis of 5-hydroxymethylfurfural (HMF) from a glucose source. The synthesis of 5-hydroxymethylfurfural (HMF) is carried out by reacting a mixture comprising a Brønsted acid, a Lewis acid, water, dimethyl sulfoxide (DMSO), acetonitrile, and a glucose source.
专利号:US-10364262-B2 优先权日:2012-07-17 标 题 :Method for the synthesis of N-phosphonomethyliminodiacetic acid 发明人:DEVAUX ALBERT; BURCK SEBASTIAN; NOTTE PATRICK 权利人:MONSANTO TECHNOLOGY LLC 摘要:A method for synthesis of N-phosphonoalkyliminodiacetic acid or derivatives thereof by forming a reaction mixture having an acid catalyst, a compound of the following general formula R1—CH2—NX—CH2—R2 and a compound having one or more P—O—P anhydride moieties to form a compound having a formula R1—CH2—N(—CH2PO3R32)(—CH2—R2) wherein in R1—CH2—NX—CH2—R2: X is —CH2—OH or —CH2—COOH; R1 and R2 are independently selected from the group consisting of nitrile, C1-C4 alkyl carboxylate, and carboxylic acid for when X is —CH2—OH, or R1 and R2 are both carbonyl groups linked by a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom; and R3 is H, an alkyl group, or an aryl group; the anhydride moieties in the P—O—P anhydride compound have one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V); and 2) hydrolyzing the mixture to form N-phosphonomethyliminodiacetic acid or one of its derivatives.
专利号:US-7728135-B2 优先权日:2005-01-06 标 题:Synthesis of CCR5 receptor antagonists 发明人:SHI XIONGWEI; ZHU MAN; LEONG WILLIAM; DAHANUKAR VILAS; ZAVIALOV ILIA A; PROIETTI CECELIA; ZHAO SHANNON; LEE HONG-CHANG; LIU YI; NGUYEN HOA N; WU WENXUE; D SA BOSCO; LIANG FENG; TRAN LOC THANH 权利人:SCHERING CORP 摘要:The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
专利号:US-7737284-B2 优先权日:2001-01-18 标题 :Synthesis of temozolomide and analogs 发明人:KUO SHEN-CHUN; MAS JANET L; HOU DONALD CHEN-TUNG 权利人:SCHERING PLOUGH CORP 摘要:This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.
专利号:EP-0442576-A1 优先权日:1990-02-13 标 题:Synthesis of cis-beta-lactams with the aid of an alkali metal compound 发明人:VAN KOTEN GERARD; VAN DER STEEN FREDERIK HENDRIK; JASTRZEBSKI JOHANN TONNS BARTH; KLEIJN HENK 权利人:UNIV UTRECHT 摘要:A synthesis of cis -β-lactams in a nearly quantitative yield by a condensation reaction of an alkali metal enolate, a substituted glycine ester and an alkali metal base, with an activated imine, is provided.
专利号:US-6818773-B2 优先权日:2001-10-15 标题:Synthesis of 4-[(Z)-4-bromophenyl)(ethoxyimino) methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbony)]-4'-methyl-1,4-′bipiperidine 发明人:CHEN MINZHANG; D SA BOSCO ANTHONY; LEONG WILLIAM W; GAN TONG; WONG GEORGE S K; TANG SUHAN; NIELSEN CHRISTOPHER MICHAEL 权利人:SCHERING CORP 摘要:In one embodiment, the present invention describes the synthesis of 4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-1'-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4'-methyl-1,4'-bipiperidine, and intermediates therefor from easily available starting materials by a simple route.
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