CAS: 60230-37-7; 2,6-Difluorobenzenesulfonamide

上下游产品

2,6-difluorobenzene-1-sulfonyl chloride 2,6-difluoroaniline N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid -2,6-difluorbenzolsulfonsaeureamidN-(4,6-Dimethoxypyrimidin-2-ylamino)-2,2,2-trichlorethyl-2,6-difluorbenzolsulfonsaeureamid N-[(2,6-Difluorophenyl)sulfonyl]-6-chloro-4-methoxy-2-pyridinecarboxamide

2,6-二氟苯磺酰氯置于氨体系中,用 四氢呋喃 作为反应溶剂,以99%的收率获得产物2,6-二氟苯磺酰胺
参考文献: 2-Amino-N-(Amino-Oxo-Aryl-Lambda6-Sulfanylidene)Acetamide Compounds And Their Therapeutic Use[fr] Composés De 2-Amino-N-(Amino-Oxo-Aryl-Lambda6-Sulfanylidène)Acétamide Et Leur Utilisation Thérapeutique
标题: 2-Amino-N-(Amino-Oxo-Aryl-Lambda6-Sulfanylidene)Acetamide Compounds And Their Therapeutic Use[fr] Composés De 2-Amino-N-(Amino-Oxo-Aryl-Lambda6-Sulfanylidène)Acétamide Et Leur Utilisation Thérapeutique
摘要:本发明一般涉及治疗化合物领域.更具体地,本发明涉及某些2-氨基-N-(氨基氧代芳基-λ6-砜基)乙酰胺化合物(以下简称为anasia化合物),该化合物在一些情况下抑制(例如,选择性抑制)细菌氨酰-Trna合成酶(aars)(例如,细菌亮氨酰-Trna合成酶,Leurs).本发明还涉及包含这种化合物的药物组合物,以及在体内外使用这种化合物和组合物来抑制(例如,选择性抑制)细菌氨酰-Trna合成酶;治疗通过抑制(例如,选择性抑制)细菌氨酰-Trna合成酶而得到改善的疾病;治疗细菌感染等.

专利信息

专利号:WO-2024115549-A1
优先权日:2022-11-30
标题:Aryl- and heteroaryl-sulfonamide derivatives as ccr8 modulators
发明人：AISSAOUI HAMED; CORMINBOEUF OLIVIER; DIETHELM STEFAN; REMEN LUBOS; RICHARD-BILDSTEIN SYLVIA
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR8 receptor modulators in medicine.