CAS: 6921-66-0; 4-Chloro-2-Hydroxyacetophenone

上下游产品

CAS号13031-39-5 3-氯乙酸苯酯 | CAS号60207-19-4 1-(4-氯-2-甲氧基苯基)乙酮 | CAS号108-43-0 3-氯酚 | CAS号75-36-5 乙酰氯 | CAS号205320-02-1 4-氯-n,2-二甲氧基-n-... | CAS号57479-70-6 2-甲氧基-4-氯苯甲酸 | CAS号99-91-2 对氯苯乙酮 | CAS号18735-81-4 4-羟基-7-氯-2H-色烯-2-酮 | CAS号103-50-4 二苄醚 | CAS号30343-35-2 6-chloro-3-meth... | CAS号18385-72-3 7-氯-4-二氢色原酮 | CAS号113850-94-5 ethyl 7-chloro-... | CAS号1148-48-7 7-chloro-2-phen... | CAS号60207-19-4 1-(4-氯-2-甲氧基苯基)乙酮 | CAS号38322-69-9 ethyl 6-chloro-...

3-氯苯酚置于aluminum (Iii) Chloride体系中,化学反应 5.0H,反应生成 4'-氯-2'-羟基苯乙酮
参考文献:Novel P-Functionalized Chromen-4-On-3-Yl Chalcones Bearing Astonishing Boronic Acid Moiety As Mdm2 Inhibitor: Synthesis,Cytotoxic Evaluation And Simulation Studies
标题:Novel P-Functionalized Chromen-4-On-3-Yl Chalcones Bearing Astonishing Boronic Acid Moiety As Mdm2 Inhibitor: Synthesis,Cytotoxic Evaluation And Simulation Studies
摘要:背景: 新型4-[3-(6/7/8-取代的4-氧代-4H-香豆素-3-基)丙烯酰基]苯硼酸衍生物(5A-H)以及其他6/7/8-取代的3-(3-氧代-3-(4-取代苯基)丙-1-烯基)-4H-香豆素-4-酮衍生物(3A-U)被设计为p53-Mdm2通路抑制剂,并据报道对多种癌细胞系具有显著的细胞毒性特性. 目的: 当前项目旨在构建香豆素-4-酮-3-基查尔酮(3A-U/5A-H)的结构-抗癌活性关系.此外,对这些香豆素-查尔酮进行了对接研究,以深入了解它们与mdm2蛋白的相互作用可能性. 方法: 利用硅胶支持的hclo4(绿色路线,收率极高)制备了29种香豆素-4-酮-3-基查尔酮衍生物(3A-U/5A-H),并对四种癌细胞系(hct116,Mcf-7,Thp-1,Ncih322)进行了测试. 结果: 在系列3A-U中,化合物3B表现出最高的抗癌活性(ic50值在8.6至28.4 µm范围内)对所有测试的癌细胞系都具有活性.有趣的是,对位硼酸衍生物(5B)显示出对结肠癌细胞系hct-116的选择性抑制作用,Ic50值为2.35 µm.除了mdm2抑制剂的标志性疏水相互作用外,衍生物5B在分子动力学(md)模拟中发现与mdm2的gln59和gln72残基有额外的氢键作用.所有化合物对正常成纤维细胞几乎无毒. 结论: 获得了具有非常好抗癌活性的新化合物,尤其是6-氯香豆素-4-酮取代硼酸衍生物5B.分子对接研究表明,作为mdm-2抑制剂,它具有非常好的活性,暗示与mdm2的疏水相互作用以及氢键作用.
DOI:10.2174/1573406415666190531123751

专利信息

专利号:US-2009247618-A1
优先权日:2008-03-26
标题 :Process for preparation of benzo-fused heteroaryl derivatives
发明人：BALLENTINE SCOTT A; REANY LAURA
权利人:BALLENTINE SCOTT A; REANY LAURA
摘要:The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.

专利号:CN-116515782-A
优先权日:2022-01-24
标题:A mutant of amine dehydrogenase and its application in the synthesis of chiral aminoalcohol compounds

专利号:CN-114751870-B
优先权日:2022-02-28
标题 :A kind of 2-(isoxazol-5-yl)phenyl-3,4-dihydroxybenzoate and its derivatives and synthesis methods and applications

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof