CAS: 1116-77-4; 4,4-Diethoxy-N,N-Dimethyl-1-Butanamine

相似化合物

16851-30-2 114094-45-0 6346-09-4

上下游产品

CAS号109-54-6 3-氯-1-(N,N-二甲基)丙胺 | CAS号122-51-0 原甲酸三乙酯 | CAS号14444-77-0 原甲酸二乙基苯酯 | CAS号50-00-0 甲醛 | CAS号6346-09-4 4-氨基丁醛缩二乙醇 | CAS号1116-78-5 TMABAL diethyl ... | CAS号64-17-5 乙醇 | CAS号19070-16-7 magnesium,N,N-d... | CAS号144034-80-0 利扎曲坦 | CAS号139264-17-8 佐米曲普坦

4-氨基丁醛缩二乙醇置于甲醇,碳酸氢钠,C.I.酸性橙108体系中,化学反应生成4-(二甲氨基)丁醛缩二乙醇
参考文献:Desaty; Keglevic,Croatica Chemica Acta,1964,Vol. 36,P. 103,106
标题:Desaty; Keglevic,Croatica Chemica Acta,1964,Vol. 36,P. 103,106

专利信息

专利号:US-7563904-B2
优先权日:2002-08-07
标题:Synthesis intermediates useful for preparing zolmitriptan
发明人：DALMASES BARJOAN PERE; ARMENGOL ASPARO MONTSERRAT
权利人:INKE SA
摘要:In particular, this invention relates to the synthesis intermediates (IV), (V), (VI) and (VIII) useful for preparing zolmitriptanzohnitriptan or a pharmaceutically acceptable salt thereof, which includes a) Ppreparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and acidification to give hydrazine (III); b) In situ Reaction of the hydrazine hydrochloride (III) with α-keto-δ-valerolactone, to give the hydrazone (IV); c) Fischer indole synthesis of the hydrazone (IV), to give the pyranoindolone of formula (V); d) Ttransesterification of the pyranoindolone (V) to provide the compound (VI), in which R means a straight or branched C1-C4 alkyl; e) Conversion of the hydroxyl group of the compound (VI) into dimethylamino to give the indolecarboxylate (VII), in which R means a straight or branched C1-C4 alkyl; f) Ssaponification of the 2-carboalkoxy group of the compound (VII), to provide indolecarboxylic acid (VIII); g) Ddecarboxylation of the indolecarboxylic acid (VIII), to provide zolmitriptan and, eventually, to provide a pharmaceutically acceptable salt thereof.

专利号:US-6160123-A
优先权日:1995-08-07
标 题:One pot synthesis of 2-oxazolidinone derivatives
发明人：PATEL RAJNIKANT
权利人:ZENECA LTD
摘要:The present invention provides an improved process for preparing (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone which comprises: a) forming a carbamate of formula (III), from methyl 4-nitro-(L)-phenylalaninate hydrochloride; b) reducing the compound of formula (III) to give the compound of formula (IV); c) reducing the methyl ester grouping in the compound of formula (IV) to give the compound of formula (V); d) ring closure of the compound of formula (V) to give the compound of formula (VI); e) diazonium salt formation from the compound of formula (VI) followed by reduction to give the compound of formula (VII); f) Fischer reaction of the compound of formula (VIl) to give (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone.

专利号:US-6084103-A
优先权日:1995-08-07
标题 :One pot synthesis of 2-oxazolidinone derivatives

专利号:US-2006264643-A1
优先权日:1995-08-07
标 题 :One Pot Synthesis of 2-Oxazolidinone Derivatives

专利号:WO-9706162-A1
优先权日:1995-08-07
标 题:One pot synthesis of 2-oxazolidinone derivatives

专利号:US-2005187274-A1
优先权日:1995-08-07
标题 :One pot synthesis of 2-oxazolidinone derivatives