CAS: 1195768-06-9; N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(Tert-Butyl)Thiazol-4-yl)-2-Fluorophenyl)-2,6-Difluorobenzenesulfonamide Methanesulfonate

上下游产品

methanesulfonic acid dabrafenib 2,6-difluorobenzene-1-sulfonyl chloride N-(3-(2-(2-chloropyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

N-(3-(2-Bromo-2-(2-Chloropyrimidin-4-yl)Acetyl)-2-Fluorophenyl)-2,6-Difluorobenzenesulfonamide置于ammonium Hydroxide体系中,用 N,N-二甲基乙酰胺,水,乙酸乙酯,乙腈 用作溶剂,化学反应生成达帕菲尼甲磺酸盐
参考文献: Combinations Of An Anti-Pd-L1 Antibody And A Mek Inhibitor And/or A Braf Inhibitor[fr] Combinaisons D'Un Anticorps Anti-Pd-L1 Et D'Un Inhibiteur De Mek Et/ou D'Un Inhibiteur De Braf
标题: Combinations Of An Anti-Pd-L1 Antibody And A Mek Inhibitor And/or A Braf Inhibitor[fr] Combinaisons D'Un Anticorps Anti-Pd-L1 Et D'Un Inhibiteur De Mek Et/ou D'Un Inhibiteur De Braf
摘要:一种新型组合物,包括mek抑制剂n-{3-[3-环丙基-5-(2-氟-4-碘苯胺基)6,8-二甲基-2,4,7-三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-D]嘧啶-1-基]苯基}乙酰胺,或其药用可接受的盐或溶剂,和/或b-Raf抑制剂,特别是n-{3-[5-(2-氨基-4-嘧啶基)-2-(1,1-二甲基乙基)-1,3-噻唑-4-基]-2-氟苯基}-2,6-二氟苯磺酰胺或其药用可接受的盐,以及一种抗pd-L1抗体;包括这些组合物的药物组合物和使用这些组合物和组合物治疗mek和/或b-Raf的抑制和/或pd-L1及其受体之间的中和或抑制相互作用有益的疾病条件的方法,例如癌症.

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-4841045-A
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-4897477-A
优先权日:1985-03-12
标题:Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-2011124867-A1
优先权日:2007-12-18
标题 :Process and intermediates for the Synthesis of heterocyclic Substituted Piperazines with CXCR3 Antagonist Activity
发明人：CHEN FRANK XING; CUTARELLI TIMOTHY D; FU XIAYONG; LIANG XIAN; MCALLISTER TIMOTHY L; ORR ROBERT K; YIN JIANGUO; YONG KELVIN H; ZHU MAN
权利人:SCHERING CORP
摘要:The present invention relates to novel processes for the preparation of the compound of the Formula A45: n n n n n n n n n n or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.

专利号:US-11008327-B2
优先权日:2017-04-21
标 题 :Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole
发明人：DA COSTA PEREIRA ROSA CARLA PATRÃ?CIA; RAMOS DAMIL JOÃO CARLOS; CORDEIRO SIMÕES ANA VANESSA; SILVA SERRA JOÃO PEDRO
权利人:TECNIMEDE SOCIEDADE TECNICO MEDICINAL SA
摘要:The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salt thereof.