CAS: 1256345-60-4; (2-Fluoro-6-Hydroxyphenyl)Boronic Acid

相似化合物

1534369-41-9 2252415-10-2 2246616-05-5

上下游产品

CAS号78495-63-3 2-氟-6-甲氧基苯基硼酸

2-氟-6-甲氧基苯硼酸置于三溴化硼体系中,用 二氯甲烷 用作溶剂,化学反应 0.17H,反应生成2-氟-6-羟基苯硼酸
参考文献:Rh / Pd催化与手性和非手性配体:氮杂二氢二苯并xepines的多米诺合成.
标题:Rh / Pd催化与手性和非手性配体:氮杂二氢二苯并xepines的多米诺合成.
摘要:多米诺骨牌游戏:通过在单个锅中将rh催化的芳基化和pd催化的c-O偶联相结合,描述了合成氮杂二氢二苯并xepinepines的合成途径.首次实现了将手性和非手性配体结合到两组分,两种金属的转化中的能力,从而使产品具有中等至非常好的收率,并具有出色的对映选择性.
Doi:10.1002/anie.201303659

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:WO-2020102730-A1
优先权日:2018-11-16
标 题:Improved synthesis of key intermediate of kras g12c inhibitor compound

专利号:US-11299491-B2
优先权日:2018-11-16
标 题:Synthesis of key intermediate of KRAS G12C inhibitor compound

专利号:US-2025206735-A1
优先权日:2018-11-16
标题:Synthesis of key intermediate of kras g12c inhibitor compound

专利号:US-12391689-B2
优先权日:2018-11-16
标题 :Synthesis of key intermediate of KRAS G12C inhibitor compound

专利号:EP-3880670-B1
优先权日:2018-11-16
标题 :Improved synthesis of key intermediate of kras g12c inhibitor compound