CAS: 15362-40-0; 1-(2,6-Dichlorophenyl)-2-Indolinone

上下游产品

CAS号15308-01-7 2,2',6'-三氯-N-苯基乙酰苯胺 | CAS号15307-79-6 双氯芬酸钠 | CAS号83281-94-1 1-(2,6-dichloro... | CAS号15307-93-4 2,6-二氯二苯胺 | CAS号15307-86-5 双氯芬酸 | CAS号83281-93-0 N-(2,6-dichloro... | CAS号83281-96-3 N-(2,6-dichloro... | CAS号3644-56-2 2-氯-n-(2,6-二氯苯基)乙酰胺 | CAS号67-56-1 甲醇 | CAS号110345-23-8 2-[[(3E)-1-(2,6... | CAS号110326-35-7 1-(2,6-dichloro... | CAS号110370-43-9 吲哚-3,6-二甲醛 | CAS号15307-79-6 双氯芬酸钠

双氯芬酸置于盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺体系中,用 二氯甲烷 用作溶剂,化学反应 0.5H,以94%的收率获得1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮
参考文献:设计为具有减少胃溃疡特性的抗炎剂的二氢吲哚衍生物的合成,体外和体外水解研究
标题:设计为具有减少胃溃疡特性的抗炎剂的二氢吲哚衍生物的合成,体外和体外水解研究
摘要:化合物 1-(2,6-Dichlorophenyl)Indolin-2-One (1),计划作为双氯芬酸 (2) 的前药,在偶联剂存在下通过分子内反应很容易合成,产率为 94% (即,Edc).化合物 1 显示出抗炎和镇痛活性,而没有胃溃疡作用.内酰胺衍生物 1 的化学和酶水解曲线未表明转化为双氯芬酸 (2).该化合物是一种用于治疗慢性炎症疾病的新型非致溃疡原型.
Doi:10.3390/molecules14093187

专利信息

专利号:CN-105037241-A
优先权日:2015-06-19
标 题 :Synthesis of 1-(2,6-dichlorophenyl)-2-indolinone

专利号:CN-111100057-A
优先权日:2019-12-04
标 题:Synthesis method of diclofenac sodium intermediate 1-(2,6-dichlorophenyl)indoline-2-one

专利号:CN-114539086-B
优先权日:2022-02-25
标题 :Synthesis method of diclofenac sodium

专利号:US-5382593-A
优先权日:1992-07-21
标 题 :New 3-(hydroxybenzylidenyl)-indolin-2-ones
发明人：LE BAUT GUILLAUME; NOURRISSON MARIE-RENEE; RENAUD DE LA FAVERIE JEAN-FRAN; BIZOT ESPIARD JEAN-GUY; CAIGNARD DANIEL-HENRI; RENARD PIERRE; ADAM GERARD
权利人:ADIR
摘要:The invention relates to a compound selected from those of formula (I): (I) wherein R1, R2, R3, R4, R5 and X are as defined in the description, its Z and E isomers, its optical isomers, in pure form or in the form of a mixture, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating a disorder resulting from or associated with peroxidation phenomena, disturbances in eicosanoid synthesis, or with platelet aggregation disorders.

专利号:CN-105037241-B
优先权日:2015-06-19
标 题:The synthesis technique of 1 (2,6 dichlorophenyl) 2 indolones