CAS: 1795-31-9; Tris(Trimethylsilyl)Phosphite

该化合物是有机磷化合物,具有硅醇和磷酸盐功能组的特征.该化合物一般呈现无色的黄色外观,以其中度的挥发性闻名.它溶于有机溶剂中,由于存在氢恐惧的三甲基组,溶解性有限.磷酸盐的存在具有一定的再活动性,在各种化学应用中有用,包括作为有机合成的试剂和聚合物配方中的潜在稳定剂或添加剂.此外,硅醇团体可以参与氢结,影响化合物的物理特性和再活性.安全数据表明,与许多有机磷化合物一样,由于潜在的毒性和环境关切,应当谨慎地处理它.

结构式图片

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10497-05-9 36198-87-5

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上下游产品

chloro-trimethyl-silane foscarnet bis(trimethylsilyl) phosphonate N,N-diethyl-1,1,1-trimethylsilanamineBis(trimethylsilyl)trifluoracetyl-phosphonat Benzyl-P,P-bis-(trimethylsilyl)phosphonoacetat bis(trimethylsilyl)(ethoxycarbonyl)phosphonate 16H32ClO4PSi3C16H32ClO4PSi3

合成工艺路线路线简述

  • 合成目标产物 Tris(Trimethylsilyl)Phosphite 主要起始原料 1-Trimethylsilyl-2-Pyrrolidinone
  • (文献来源)合成步骤主要原料 1-Trimethylsilyl-2-Pyrrolidinone
三甲基溴硅烷置于三甲氧基磷体系中,用 氯仿 用作溶剂,化学反应 24.0H,反应生成三(三甲代甲硅烷基)亚磷酸盐
参考文献:氨基甲烷膦酸的新型吡喃酮,色酮和香豆素衍生物的合成
标题:氨基甲烷膦酸的新型吡喃酮,色酮和香豆素衍生物的合成
摘要:摘要 通过用亚磷酸三(三甲基甲硅烷基)酯处理杂环醛和胺的混合物,随后用甲醇对形成的甲硅烷基化产物进行溶剂分解,一步法制备了氨基甲膦酸的新型吡喃酮,色酮和香豆素衍生物.
Doi:10.1080/00397910008087219

专利信息


专利号:US-4937367-A
优先权日:1987-07-15
标 题:Process for the preparation of intermediates for the synthesis of fosfomycin
发明人:CASTALDI GRAZIANO; GIORDANO CLAUDIO
权利人:ZAMBON SPA
摘要:A process is described for the preparation of intermediates useful in the synthesis of Fosfomycin. n More particularly, an enantioselective process is described for the preparation of derivatives of (1S,2S)-1,2-dihydroxypropyl-phosphonic acid of formula ##STR1## wherein R 2 and R 3 have the meanings reported in the specification.

专利号:US-11713331-B2
优先权日:2020-04-12
标 题 :Benzene 1,4-bis(bisphosphonic acid)-based metal complexes, method of synthesis and applications thereof
发明人:LOPEZ-MEJIAS VILMALI; CARMONA-SARABIA LESLY Y; ESCALERA JOY ANDREA M; MOJICA VAZQUEZ DARILYS
权利人:LOPEZ MEJIAS VILMALI; CARMONA SARABIA LESLY Y; ESCALERA JOY ANDREA M; MOJICA VAZQUEZ DARILYS; UNIV PUERTO RICO
摘要:The invention provides extended bisphosphonate-based metal complexes using benzene1,4-bis(bisphosphonic acid) (BBPA), an analog of benzene 1,4-dicarboxylic acid (BDC). Hydrothermal synthesis of BBPA with the bioactive metals Ca 2+ , Zn 2+ , and Mg 2+ leads to four crystals phases, namely, BBPA-Ca forms I and II, BBPA-Zn form I, and BBPA-Mg form I. Out of the three structures, BBPA-Ca form II presents large channels (8 Å×12 â„«), potentiating the use of this framework to load drugs. Cytotoxicity effects of BBPA was elucidated in a human breast cancer MDA-MB-231 and a normal osteoblast hFOB 1.19 cell lines. The half-maximal inhibitory concentration (IC 50 ) for BBPA used to treat both cell lines were >200 μM at 24, 48, and 72 h of treatment. The BBPA in the range of concentration employed (0-200 μM) was not cytotoxic against these cell lines.

专利号:US-2025313471-A1
优先权日:2024-03-29
标题 :Mechanochemical reduction of phosphates as a sustainable route to phosphite salts and organophosphite compounds
发明人:LOEWE PAWEL; CUMMINS CHRISTOPHER C; TAAKILI RACHID; XIN (DECEASED) TIANSI
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed herein, among other things, are methods for the mechanochemical synthesis of phosphite salts and organophosphite compounds from phosphates, such as condensed phosphates.

专利号:US-8445695-B2
优先权日:2003-10-31
标 题 :Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
发明人:LINDSEY JONATHAN S; LOEWE ROBERT S; MUTHUKUMARAN KANNAN; AMBROISE AROUNAGUIRY
权利人:LINDSEY JONATHAN S; LOEWE ROBERT S; MUTHUKUMARAN KANNAN; AMBROISE AROUNAGUIRY; UNIV NORTH CAROLINA STATE; ZETTACORE INC
摘要:A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.

专利号:US-7338669-B2
优先权日:2004-02-02
标 题:Inorganic boranophosphate salts
发明人:FISCHER BILHA; NAHUM VICTORIA
权利人:UNIV BAR ILAN
摘要:The invention provides novel inorganic boranophosphate salts that can be used as fertilizers, in detergent formulations, as additive in melts for the glass industry, in boron neutron-capture therapy of cancer, and as synthetic building blocks in the synthesis of boranonucleotides of various lengths.

专利号:US-2024287106-A1
优先权日:2021-06-09
标题 :Method for Producing Fluorescent Probe Library Using Solid-Phase Extraction and Method of Measuring Enzyme Activity Using Same
发明人:KOMATSU TORU; URANO YASUTERU; SAKAMOTO SHINGO; WATANABE RIKIYA; KAGAMI YU
权利人:UNIV TOKYO; RIKEN
摘要:To provide a synthesis scheme capable of easily synthesizing various kinds of fluorescent probes. A method for preparing a compound represented by Formula (III) below, the method including steps (1) to (5).
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合成参考文献


摘要:Kimura, T., Science of Synthesis Knowledge Updates, (2016) 2, 451.
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