CAS: 190774-50-6; 2-Fluoro-5-Methylphenylisocyanate

上下游产品

2-氟-5-甲基苯胺 3-Amino-4-Fluorotoluene 452-84-6

2-氟-5-甲基苯胺 反应生成异氰酸2-氟-5-甲基苯酯
参考文献:N-(4-(3-氨基-1H-吲唑-4-基)苯基)-N'-(2-氟-5-甲基苯基)脲及其中间体的制备方法
标题:N-(4-(3-氨基-1H-吲唑-4-基)苯基)-N'-(2-氟-5-甲基苯基)脲及其中间体的制备方法
摘要:本发明提供了n-(4-(3-氨基-1H-吲唑-4-基)苯基)-N'-(2-氟-5-甲基苯基)脲及其中间体的制备方法.具体地,本发明提供了一种式i硼酸酯化合物的制备方法,包括步骤:式iii化合物与式iv化合物反应生成式v化合物,以及式v化合物与硼试剂反应,生成式i化合物.本方法具有反应方便,中间体易得,收率高,产品纯度可达98.5%以上,原料成本低等特点,适合工业化生产.

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:CN-104250245-A
优先权日:2013-06-25
标 题:1-(5-(2-Aminobenzo[d]oxazol-5-yl)-1,3,4-thiadiazol-2-yl)-3-(2-fluoro-5-methylphenyl ) Synthesis and application of urea