CAS: 332-42-3; 1-Fluoro-4-(2-Bromoethyl)Benzene

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CAS号7589-27-7 对氟苯乙醇 | CAS号497-19-8 纯碱 | CAS号7789-60-8 三溴化磷 | CAS号405-50-5 对氟苯乙酸 | CAS号70931-33-8 1-[2-(4-氟苯基)乙基]哌嗪 | CAS号70931-13-4 11-chloro-7-flu... | CAS号352-13-6 4-氟苯基溴化镁 | CAS号6529-53-9 1-(2-溴乙基)-4-氯苯 | CAS号405-99-2 4-氟苯乙烯 | CAS号459-31-4 3-(4-氟苯基)丙酸 | CAS号70931-33-8 1-[2-(4-氟苯基)乙基]哌嗪 | CAS号6529-53-9 1-(2-溴乙基)-4-氯苯 | CAS号139290-69-0 (+)-α-(2,3-二甲氧基... | CAS号350-35-6 1-(对氟苯基)-1,2-二溴乙烷 | CAS号134069-53-7 3-benzyl-8-[2-(... | CAS号1583-88-6 4-氟苯乙胺 | CAS号175673-57-1 (S)-(2,3-二甲氧基苯基...

4-氟苯基溴化镁置于乙醚,三溴化磷,苯体系中,化学反应生成 4-氟溴乙基苯
参考文献:加压型的一些氟化胺
标题:加压型的一些氟化胺
摘要:从反应获得的2-甲基-2-羧基-1,2,3,4-四氢萘-1-丁酸的二甲酯是液体.从 5.52 克.得到4.56克丙酸酯.(75%) 的产品在 0.5 毫米处"升华"了 190-200".将四分之六的上述酯在氮气氛中通过甲醇钠以与前述环化完全相同的方式进行环化,得到 11-甲基-1-酮基-2-碳甲氧基-1,2,3,4,9,10,11,12-八氢菲(X),其在室温下为液体但在约10'静置时固化.在 0.5 毫米处以 170-180°"升华"的环化产物.没有得到分析纯.将上述获得的环化酮酯在氮气氛中以前述方式水解,得到1.9G.甲基酮八氢菲的(来自丁酸酯的产率为 59%)在 100-150 英寸处"升华"到 0.6 毫米.产物为液体,其获得的不是分析纯的.xi的缩氨基脲形成小的无色晶体;mp 210.5-212.6',在预热浴中分解.肛门.计算.对于 Cleh210N8:N,15.5,发现:N,15
DOI:10.1021/ja01847A069

专利信息

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:CN-119819362-A
优先权日:2025-01-03
标题 :A photocatalyst for the efficient catalytic synthesis of halogenated aromatic hydrocarbons and its preparation method and application

专利号:US-5302595-A
优先权日:1988-10-04
标题:Muscarinic receptor antagonists
发明人：CROSS PETER E; MACKENZIE ALEXANDER R
权利人:PFIZER
摘要:Compounds of the formula I ##STR1## wherein X, Y and v are as defined below, novel intermediates used in their synthesis, and the pharmaceutically acceptable salts of such compounds and intermediates. The compounds of formula I and the novel intermediates used in their synthesis are muscarinic receptor antagonists that are selected for smooth muscle muscarinic sites and are useful in the prevention and treatment of diseases associated with altered motility or tone of smooth muscle, such as irritable bowel syndrome, diverticular disease, urinary incontinence, aesophageal achalasia, and chronic obstructive airways disease.

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:CN-119390627-A
优先权日:2024-10-31
标 题:Synthesis method of photocatalytic asymmetric thioether compound

专利号:RU-2131418-C1
优先权日:1992-12-16
标题:Compounds inhibiting aromatase activity selectively, method of synthesis, pharmaceutical composition