CAS: 51-42-3; (-)-Epinephrine (+)-Bitartrate Salt

盐酸肾上腺酮置于氢气,Palladium(II) Hydroxide体系中,用 甲醇,水 作为反应溶剂,10.0~40.0 °C,20.0 Kpa 条件下,反应 36.0H,反应生成 酒石酸肾上腺素
参考文献: Process For The Preparation Of Optically Enriched Adrenaline[fr] Procédé De Préparation D'Adrénaline Enrichie Optiquement
标题: Process For The Preparation Of Optically Enriched Adrenaline[fr] Procédé De Préparation D'Adrénaline Enrichie Optiquement
摘要:提供了一种生产(-)-肾上腺素和(-)-肾上腺素-L-酒石酸盐的过程.该过程提供了一种新的,高效且商业可行的对消旋肾上腺素进行光学分辨的方法.在一个方面,提供了一种合成(-)-肾上腺素的一锅法过程.该过程提供了一种简单且成本较低的方法,可用于制备符合api质量标准的商业规模批次的(-)-肾上腺素和(-)-肾上腺素-L-酒石酸盐.该过程避免了使用昂贵且不可预测的手性催化剂.

专利信息

专利号:US-2021061757-A1
优先权日:2018-04-13
标题:Process for the synthesis of optically active beta-amino alcohols
发明人：NISIC FILIPPO; GARIS FARIS; COLLI CORRADO; BERTOLINI GIORGIO; SADA MARA; BERTUOLO STEFANIA; RONZONI SILVANO; DI FABIO ROMANO; MAIORANA STEFANO
权利人:OLON SPA
摘要:Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invention are said novel synthesis intermediates and their use for the preparation of active pharmaceutical ingredients.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:CA-3096434-A1
优先权日:2018-04-13
标 题 :Process for the synthesis of optically active beta-amino alcohols