CAS: 57-91-0; 17α-Estradiol

上下游产品

CAS号3434-76-2 3-O-甲基17α-雌二醇 | CAS号53-16-7 雌酚酮 | CAS号71-41-0 正戊醇 | CAS号6639-99-2 17ALFA-双氢马烯雌酮 | CAS号55105-93-6 N-[(E)-[(13S)-3... | CAS号99-35-4 1,3,5-三硝基苯 | CAS号64-17-5 乙醇 | CAS号2393-53-5 3-Hydroxyestra-... | CAS号555-31-7 异丙醇铝 | CAS号50-28-2 雌二醇

诺龙置于二苯基-2-吡啶膦,Potassium Hydroxide,Lithium Bromide,Copper(Ll) Bromide体系中,用 乙醇,水,乙酸乙酯,甲苯 作为反应溶剂,化学反应 50.5H,反应生成 α-雌二醇
参考文献:一种[3-14C]标记的17α-雌二醇的制备方法
标题:一种[3-14C]标记的17α-雌二醇的制备方法
摘要:本发明属于放射性同位素 14 C标记的化合物合成技术领域.本发明提供了一种[3‑ 14 C]标记的17α‑雌二醇的制备方法,包括以下步骤:以17β‑酰化烯醇内酯和 14 C标记的乙酰氯为起始原料,经缩合反应,第一水解反应,光延反应,芳香化反应和第二水解反应,即得到[3‑ 14 C]标记的17α‑雌二醇,本发明具有合成成本低,路线短,产品收率高的优点;此外,本发明提供的制备方法操作简单,适宜规模化生产.

专利信息

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-6350739-B1
优先权日:1999-08-11
标 题:Methods of prevention and treatment of ischemic damage
发明人：SIMPKINS JAMES W; COVEY DOUGLAS F
权利人:UNIV FLORIDA RESARCH FOUNDATIO; UNIV WASHINGTON
摘要:The present invention in various embodiments provides methods of treating stroke and conferring protection on a population of cells associated with ischemia in a subject following an ischemic event, comprising: (a) providing an estrogen compound; and (b) administering the effective amount of the compound over a course that includes at least one dose within a time that is effectively proximate to the ischemic event, so as to confer protection on the population of cells. Novel methods are provided for the delivery of an estrogen compound. Examples of ischemic events treatable according to the invention are cerebrovascular disease or stroke, subarachnoid subhemorrhage, myocardial infarct, surgery and trauma. A method of treating ischemic damage utilizing hormones that are non-sex hormones is also provided. A method of treating stroke with ent-17β-estradiol, and a method of synthesis, and compounds produced from the synthesis are provided.

专利号:US-4496555-A
优先权日:1983-07-19
标题:Compounds and compositions for inhibiting estrogen sulfotransferase transferase activity, process and novel intermediates therein
发明人：BROOKS SAMUEL C; HORWITZ JEROME P
权利人:UNIV WAYNE STATE
摘要:The present invention concerns the novel compounds having fluoro, amino, nitro or hydroxy monosubstituted at the 2- or 4- position on deoxyestrone as well as deoxyestra-17-ol. The compounds are useful as estrogen sulfotransferase inhibitors. Such estrogen sulfotransferase inhibition provides the novel use for treating a female mammal to prevent implantation of a blastocyst. Additionally, the invention concerns the novel synthesis and novel intermediates in the synthesis of the estrogen sulfotransferase inhibiting compound of the present invention.

专利号:US-2003158432-A1
优先权日:2002-01-08
标 题:Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex

专利号:US-6150403-A
优先权日:1997-10-14
标 题 :Topical compositions for regulating the oily/shiny appearance of skin
发明人：BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J
权利人:PROCTER & GAMBLE
摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.

专利号:US-2007225512-A1
优先权日:2002-01-08
标 题 :Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex