CAS: 92-70-6; 3-Hydroxy-2-Naphthoic Acid

• 英文名称3-Hydroxy-2-Naphthoic Acid
• 中文名称2-羟基-3-萘甲酸
• IUPAC名称3-hydroxy-2-naphthoic acid
• 其它别名2-Hydroxy-3-Napthoic Acid; 3-Hydroxy-2-Naphthalenecarboxylic Acid [hsdb]; 3-Hydroxy-2-Napthoic Acid; Bzj; Naphthol B.O.N.; 3-Hydroxy-2-Naphthoic Acid, ; 3-Hydroxy-Beta-Naphthoic Acid; C.I. Developer 20
• CAS编号92-70-6
• MFCD编号:MFCD00004103
• EINECS号:202-180-8
• FDA UNII编号:C7S9D784HX
• 分子式:C11H8O3
• 分子量:188.18
• 产品CID: 1965718
• 产品分类有机原料 → 羧酸类化合物及衍生物 → 羧酸的卤化、磺化、硝化或亚硝化衍生物

• 相似结构搜索
• InChIKey: ALKYHXVLJMQRLQ-UHFFFAOYSA-N
• InChI=1S/C11H8O3/c12-10-6-8-4-2-1-3-7(8)5-9(10)11(13)14/h1-6,12H,(H,13,14)…
• 计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数1.0

物理性质

• 熔点218-221 °C(文献)
• 沸点283.17°C (粗估)
• 闪点>150°C
• 密度1.43 g/cm3 (23°C)
• pKa:3.02±0.30(预测)
• PSA:57.53
• LogP:2.2436
• 折射率1.7160 (估算)
• 蒸汽压Vapor pressure, Pa at 25 °C: (negligible)
• 溶解性0.072G/l Practically Insoluble
• 外观形态黄色至米棕色细结晶粉末
• 储存条件密封, 常温干燥保存
• 产品应用主要用于制造色酚AS及其他各种色酚的中间体,也是制作医药和有机颜料的中间体.
• 性质描述黄色斜方片晶.熔点218-221°C.溶于乙醇,乙醚,苯,氯仿和苛性碱溶液,不溶于水.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS05;
  注释: Exclamation mark & Corrosion
• 危险类别急性毒性 类别4(经口)
  严重眼刺激 类别2
  特定目标器官毒性 - 单次接触 类别3
  严重眼损伤 类别1
  水生慢性毒性 类别3
  致突变性 类别2
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2A
• 警示词Danger(危险)
• 危险描述H302 |吞咽有害.
  H319 |造成严重眼刺激.
  H335 |可能引起呼吸道刺激.
  H318 |造成严重眼损伤.
  H412 |对水生生物有害并具有长期持续影响.
  H341 |怀疑导致遗传缺陷.
  H315 |造成皮肤刺激.
• 防范说明P261-P264-P273-P280-P301+P312-P305+P351+P338
• UN编号NONH for all modes of transport
• 危险品标志Xn,Xi
• 安全声明26-37/39
• 危险类别码22-36-36/37/38
• WGK Germany1

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 3-Hydroxy-2-Naphthoic Acid 主要起始原料 Sodium 2-Naphtholate
• 135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Sodium Hydroxide; 150 - 200 °C; 200 °C -> 240 °C; 5 H,240 °C1.2 2 H,260 °C1.3 Solvents: Water; 1 H,100 °C1.4 Reagents: Sulfuric Acid Solvents: Water; Ph 5.51.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:An Improved Process For The Manufacture Of Bon Acid
  参考文献:India]
  
  135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Sulfuric Acid Solvents: Water; Rt -> 50 °C; 10 Min,Ph 6.0 - 6.2,50 °C1.2 Reagents: Sodium Bicarbonate; Ph 6.8 - 7.01.3 Reagents: Sulfuric Acid Solvents: Water; Rt -> 95 °C; 95 °C
  标题:A Novel Method For The Neutralization And Acidification Process Of 2-Hydroxy-3-Naphthoic Acid
  作者:Yang,Lixian; Hu,Qinghua; Shi,Quanda; Meng,Mingyang
  参考文献:Ranliao Yu Ranse 日期:2008 卷标:45(1) 页码:40-43]
  
  574001-88-0 = 92-70-6
  反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: (4Ar,8Ar)-Decahydro-1,5-Naphthyridine Solvents: Water; Ph 141.2 Catalysts: Cuprous Iodide Solvents: Dimethylformamide,Acetonitrile,1,2-Dichloroethane; 10 - 15 Min,Rt1.3 Reagents: Oxygen Solvents: Dimethylformamide,Acetonitrile,1,2-Dichloroethane; 24 H,80 °C
  标题:Enantioselective Oxidative Biaryl Coupling Reactions Catalyzed By 1,5-Diazadecalin Metal Complexes: Efficient Formation Of Chiral Functionalized Binol Derivatives
  作者:Li,Xiaolin; Hewgley,J. Brian; Mulrooney,Carol A.; Yang,Jaemoon; Kozlowski,Marisa C.
  参考文献:Journal Of Organic Chemistry 日期:2003 卷标:68(14) 页码:5500-5511]
  
  93-09-4 = 92-70-6
  反应条件:1.1 Reagents: Quinone,Potassium Acetate,Oxygen Catalysts: Palladium Diacetate Solvents: Dimethylacetamide; 15 H,115 °C; 115 °C -> Rt
  标题:Pd(Ii)-Catalyzed Hydroxylation Of Arenes With 1 Atm Of O2 Or Air
  作者:Zhang,Yang-Hui; Yu,Jin-Quan
  参考文献:Journal Of The American Chemical Society 日期:2009 卷标:131(41) 页码:14654-14655]
  
  17201-44-4 + 135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Carbon Dioxide; 5 H,100 Atm,190 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
  标题:Carboxylation Of Hydroxy Arenes By Alkaline Metal Salts Of Ethylcarbonic Acid
  作者:Shalmagambetov,K. M.; Suerbaev,Kh. A.
  参考文献:Khimicheskaya Tekhnologiya (Moscow 日期:2011 卷标:12(10) 页码:598-603]
  
  135-19-3 = 92-70-6
  反应条件:1.1 -1.2 Reagents: Sodium Hydroxide Solvents: Water1.3 Reagents: Sulfuric Acid Solvents: Water
  标题:Method For Producing High-Purity 2-Hydroxy-3-Naphthoic Acid
  参考文献:China]
  
  17201-44-4 + 135-19-3 = 92-70-6
  反应条件:1.1 5 H,10 Atm,190 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Carboxylation Of Naphthols With Sodium Ethyl Carbonate
  作者:Suerbaev,Kh. A.; Mikhnenko,O. E.; Akhmetova,G. B.; Shalmagambetov,K. M.; Chepaikin,E. G.
  参考文献:Neftekhimiya 日期:2005 卷标:45(5) 页码:364-366]
  
  135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 1 H,Rt1.2 2 H,240 °C1.3 Reagents: Sulfuric Acid; Acidified,Rt
  标题:Synthesis Of Nanodispersible 6-Aryl-2,4-Diamino-1,3,5-Triazine And Its Derivatives
  作者:Padalkar,Vikas S.; Patil,Vikas S.; Phatangare,Kiran R.; Gupta,Vinod D.; Umape,Prashant G.; Et Al
  参考文献:Materials Science & Engineering 日期:2010 卷标:170(1-3) 页码:77-87]
  
  93-09-4 = 92-70-6
  反应条件:1.1 Reagents: Quinone,Potassium Acetate,Oxygen Catalysts: Palladium Diacetate Solvents: Dimethylacetamide; 15 H,1 Atm,115 °C
  标题:Process For Pd(Ii)-Catalyzed Hydroxylation Of Arenes With O2 Or Air
  参考文献:World Intellectual Property Organization]
  
  135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Ethyl Bromide,Magnesium Solvents: Diethyl Ether1.2 Solvents: Carbon Disulfide1.3 Reagents: Ammonium Chloride Solvents: Water
  标题:Metal Template Ortho-Acylation Of Phenols. Direct Synthesis Of Salicylic Acid Chlorides And Derivatives
  作者:Sartori,Giovanni; Casnati,Giuseppe; Bigi,Franca; Bonini,Giovanni
  参考文献:Synthesis 日期:1988 卷标:(10) 页码:763-6]
  
  93-09-4 = 92-70-6
  反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,Quinone,Potassium Acetate Catalysts: N-Acetyl-L-Isoleucine,Palladium Diacetate Solvents: 1,2-Dimethoxyethane,Water; 100 °C
  标题:Palladium-Catalyzed Ortho-C-H Hydroxylation Of Benzoic Acids
  作者:Luo,Feihua; He,Shuhua; Gou,Quan; Chen,Jinyang; Zhang,Mingzhong
  参考文献:Tetrahedron Letters 日期:2021 卷标:84]
  
  135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Sodium 2-Naphtholate Solvents: Water; Rt -> 160 °C; 160 °C; 160 °C -> 280 °C; 1 H,280 °C1.2 290 °C; 1.8 H,0.6 Mpa,290 °C; 290 °C -> 90 °C
  标题:Process For The Dehydration Of Hydrous Sodium β-Naphtholate
  参考文献:European Patent Organization]
  
  875-83-2 = 92-70-6
  反应条件:1.1 15 Min,0.4 - 0.7 Mpa,220 - 235 °C; 10 Min,0.4 - 0.7 Mpa,220 - 235 °C; 70 Min,0.4 - 0.7 Mpa,220 - 235 °C; 20 Min,0.4 - 0.7 Mpa,220 - 235 °C
  标题:Method For Preparing 2-Hydroxy-3-Naphthoic Acid Using 2-Naphthol
  参考文献:China]
  
  36294-21-0 + 463-79-6 = 92-70-6
  反应条件:1.1 230 °C
  标题:On The Identification Of The β-Oxynaphthoic Acid With A Melting Point Of 216°C
  作者:Hosaeus,H.
  参考文献:Berichte Der Deutschen Chemischen Gesellschaft 日期:1893 卷标:26(1) 页码:665-673]
  
  135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Sodium Hydroxide; 0.4 H,0.23 Mpa,125 °C; 25 Min,0.098 Mpa,225 °C1.2 65 Min,0.5 Mpa; 20 Min1.3 Reagents: Sulfuric Acid; Ph 4.8,225 °C -> 55 °C
  标题:Preparation Of 2-Hydroxy-3-Naphthoic Acid
  参考文献:China]
  
  93-09-4 = 92-70-6
  反应条件:1.1 Reagents: Quinone,Potassium Acetate,Oxygen Catalysts: Palladium Diacetate Solvents: Dimethylacetamide; 15 H,1 Atm,115 °C
  标题:A Versatile Approach For The Synthesis Of Para-Substituted Arenes Via Palladium-Catalyzed C-H Functionalization And Protodecarboxylation Of Benzoic Acids
  作者:Pan,Shulei; Zhou,Bo; Zhang,Yanghui; Shao,Changdong; Shi,Guangfa
  参考文献:Synlett 日期:2016 卷标:27(2) 页码:277-281]
  
  135-19-3 = 92-70-6
  反应条件:1.1 0.4 - 0.6 Mpa,235 °C; 235 °C -> 250 °C; 250 °C -> 225 °C; 0.4 - 0.6 Mpa,225 °C -> 265 °C
  标题:A Process For Preparing 3-Hydroxy-2-Naphthalenecarboxylic Acid
  参考文献:China]
  
  17201-44-4 + 135-19-3 = 92-70-6
  反应条件:1.1 1 H,Rt -> 60 °C; 4 H,10 Atm,60 °C -> 190 °C; 1 H,190 °C; 190 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,Rt
  标题:Carboxylation Of Hydroxyarenes With Metal Alkyl Carbonates
  作者:Suerbaev,Khakim A.; Aldabergenov,Mayliby K.; Kudaibergenov,Nurbolat Zh.
  参考文献:Green Processing And Synthesis 日期:2015 卷标:4(2) 页码:91-96]
  
  135-19-3 = 92-70-6
  反应条件:1.1 Reagents: Sodium Hydroxide1.2 -1.3 Reagents: Sulfuric Acid Solvents: Water; Ph 5 - 5.8
  标题:Method For Increasing Content Of 2-Hydroxy-3-Naphthoic Acid Produced By Gas-Solid Phase Process
  参考文献:China]
  
  = 92-70-6
  反应条件:1.1 Catalysts: Pseudomonas Putida
  标题:Oxidation Of Aromatic Condensed Ring Hydrocarbon With Pseudomonas
  参考文献:Japan

海关参考信息

• 2902902000-精萘
  2905110000-甲醇
  2906210000-苄醇
  2912110000-甲醛
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