CAS: 117977-21-6; 2-[[[4-(3-Methoxypropoxy)-3-Methylpyridine-2-Yl ]Methyl]Thio]-1H-Benzimidazole

上下游产品

CAS号117977-20-5 2-(氯甲基)-4-(3-甲氧... | CAS号134469-07-1 1H-苯并咪唑-2-硫醇 | CAS号103312-62-5 2-(4-氯-3-甲基-2-吡... | CAS号1589-49-7 3-甲氧基-1-丙醇 | CAS号37699-43-7 2,3-二甲基-4-硝基吡啶-N-氧化物 | CAS号59886-90-7 2,3-二甲基-4-氯吡啶-N-氧化物 | CAS号117976-90-6 雷贝拉唑钠 | CAS号117976-89-3 雷贝拉唑 | CAS号117976-47-3 雷贝拉唑钠杂质 A

2-羟甲基-4-甲氧基丙氧基-3-甲基吡啶置于氯化亚砜,乙醇,Sodium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应 4.0H,反应生成2-[[[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基]硫代]-1H-苯并咪唑
参考文献:2-甲基吡啶n-氧化物中甲基c(sp 3)-H键的无金属和无碱区域选择性硫醇化
标题:2-甲基吡啶n-氧化物中甲基c(sp 3)-H键的无金属和无碱区域选择性硫醇化
摘要:通过tfaa介导的吡啶n-氧化物的[3,3]-σ重排和tbab催化的三氟乙酸盐在金属和金属催化下直接转化为三氟乙酸的反应,可以开发一锅两步的吡啶-2-基甲基硫醚合成方法无碱条件.这种方法可以使未活化的甲基c(sp 3硫醇化)-2-甲基吡啶与硫醇的氢键.该方法的显着特征包括区域选择性高,阶跃和原子经济,条件温和,操作简单,底物范围广和可扩展性.此外,该方法已成功地用于合成奥美拉唑硫化物和雷贝拉唑硫化物,而无需tbab催化.全面的绿色化学指标分析表明,该方法比报道的雷贝拉唑硫化物更有效,更环保.
Doi:10.1039/c8Gc03072C

专利信息

专利号:US-7638633-B2
优先权日:2005-02-21
标题 :Process for synthesis of proton pump inhibitors
发明人：PATHI SRINIVAS LAXMINARAYAN; KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA
权利人:CIPLA LTD
摘要:A process for preparation of rabeprazole sodium comprising oxidation of wet or dry rabeprazole sulphide with sodium hypohalite in water or a mixture of water and water miscible solvent using alkali metal hydroxide and catalyst is disclosed herein. The present invention also discloses process for preparation of rabeprazole sulphide.

专利号:US-9631181-B2
优先权日:2009-12-08
标 题 :Synthesis of prazole compounds
发明人：BONG YONG KOY; CLAY MICHAEL D; COLLIER STEVEN J; MIJTS BENJAMIN; VOGEL MICHAEL; ZHANG XIYUN; ZHU JUN; NAZOR JOVANA; SMITH DEREK J; SONG SHIWEI
权利人:CODEXIS INC
摘要:The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

专利号:US-2008161579-A1
优先权日:2005-02-21
标题 :Process for Synthesis of Proton Pump Inhibitors

专利号:CA-2606799-C
优先权日:2005-02-21
标题 :Process for synthesis of proton pump inhibitors

专利号:AU-2006242782-B2
优先权日:2005-02-21
标题 :New process for synthesis of proton pump inhibitors

专利号:AU-2006242782-A1
优先权日:2005-02-21
标题 :New process for synthesis of proton pump inhibitors