CAS: 2164-61-6; Pyridazine-3-Carboxylic Acid

上下游产品

(Methyl-{2-[(pyridazine-3-carbonyl)-amino]-acetyl}-amino)-acetic acid 1,2-diazine 3-(phenyltrimethylsiloxymethyl)-pyridazine 3-(4-chlorophenyltrimethylsiloxymethyl)-pyridazine 3-(4-methoxyphenyltrimethylsiloxymethyl)-pyridazine

3-甲基哒嗪置于吡啶,Selenium(Iv) Oxide,水体系中,化学反应 21.0H,反应生成3-羧基哒嗪
参考文献:基于非铁(II)的传感器:晶体学洞察到一系列由客体引起的定势变换的循环
标题:基于非铁(II)的传感器:晶体学洞察到一系列由客体引起的定势变换的循环
摘要:能够通过一组易于监视的输出来在室温下感测挥发性客体的材料对于发展为小型挥发性有机物和有毒气体的化学传感器具有极大的吸引力.本文中的双核铁(II)配合物,的[fe Ii 2(大号)2(ch 3 Cn)4 ](bf 4)4 ⋅2Ch 3 Cn(1)[大号= 4-(4-甲基苯基)-3-(3-吡啶哒嗪基)-5-吡啶基-4H-1,2,4-三唑]被证明在暴露于不同客体蒸气下会经历可逆的单晶至单晶(scsc)转化:1(mecn )⇌ 2(乙醇)-> 3(h 2 O)⇌ 1(mecn中).当1和2保持双金属状态时,Scsc至3涉及转化为一维聚合物链(由于l桥接模式的改变),该链显着地可以进行scsc解聚,从而重整双金属1.此外,对两个有序瞬态形式1Tf3和2Tf3的sc‐xrd研究证实,随着旧来宾的离开,新来宾扩散到无孔晶格中,从而发生了来宾交换.这些可逆的scsc事件还引起颜色和磁响应.确实,深红色1具有自旋交叉活性(t
Doi:10.1002/anie.201608813

专利信息

专利号:US-2023405565-A1
优先权日:2022-06-21
标 题:Catalyst composition for biaryl synthesis by decarboxylative cross-coupling
发明人：LIM CHERN-HOOI; QIAN GANG; ELDER WILLIAM ZACHARY; RILEY PAIGE; KOLVENBACH ROBIN; WALTER PHILIPP; GOCK MICHAEL
权利人:HERAEUS DEUTSCHLAND GMBH & CO KG; NEW IRIDIUM INC
摘要:The present invention relates to a catalyst composition for synthesis of heteroaromatic biaryls by a light-assisted decarboxylative carbon-carbon cross-coupling reaction, wherein the composition comprises(i) a palladium compound which is selected from a palladium salt or a palladium complex or a mixture thereof,(ii) at least one of the following compounds:a compound of Formula (I)a compound of Formula (II)an iridium complex comprising ligands L1, L2 and L3, wherein the ligands L1, L2 and L3 are selected, independently from each other, from a phenylpyridine and a bipyridine.

专利号:WO-2025078335-A1
优先权日:2023-10-09
标 题 :Processes for the preparation of deucravacitinib
发明人：ETAYO PÉREZ PABLO; PUJOL OLLÉ XAVIER; MOLINA NIETO JUAN
权利人:FARMHISPANIA GROUP S L
摘要:The invention relates to processes for the preparation of deucravacitinib of formula (XI), or a pharmaceutically acceptable salt thereof. It also relates to intermediates of formula (V') and (V'') as defined herein useful in the synthesis of this molecule.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-0107416-A1
优先权日:1999-07-28
标题 :Method of producing pyridazine carboxylic acid derivatives
发明人：BESSARD YVES; CRETTAZ ROGER; EGGEL MICHAEL
权利人:LONZA AG; BESSARD YVES; CRETTAZ ROGER; EGGEL MICHAEL
摘要:The invention relates to a method of producing pyridazine carboxylic acid derivatives of the general formulae (Ia) or (Ib), wherein R<1> represents a group of the formula -OR<3> or -NR<4>R<5>, R<2> represents hydrogen, chlorine, a group of the formula -OR<6> or a group of the formula -NR<7>R<8>, R<3> represents C1-10 alkyl, C3-8 cycloalkyl or aryl-C1-4-alkyl, R<4> represents C1-10 alkyl, C3-8 cycloalkyl, optionally substituted aryl or aryl-C1-4-alkyl, R<5> represents hydrogen, C1-10 alkyl, C3-8 cycloalkyl, optionally substituted aryl or aryl-C1-4-alkyl and R<6> represents C1-10 alkyl, C3-8 cycloalkyl, aryl-C1-4-alkyl or an optionally substituted aromatic or heteroaromatic rest and R<7> and R<8> represent independently C1-10 alkyl, C3-8 cycloalkyl or aryl-C1-4-alkyl or together with the nitrogen atom form a saturated or aromatic heterocyclic ring. The inventive derivatives are obtained by reacting the corresponding 3-chloropyridazines or 3,6-dichloropyridazine with carbon monoxide and alcohols or amines H-R<1> in the presence of palladium-phosphin complexes and bases. The pyridazine carboxylic acid derivatives (Ia, Ib) are the intermediates for the synthesis of pharmaceutically active substances.

专利号:US-2023406826-A1
优先权日:2022-06-21
标 题 :Use of a catalyst composition for biaryl synthesis by decarboxylative cross-coupling
发明人：LIM CHERN-HOOI; QIAN GANG; ELDER WILLIAM ZACHARY; RILEY PAIGE; KOLVENBACH ROBIN; WALTER PHILIPP; GOCK MICHAEL
权利人:HERAEUS DEUTSCHLAND GMBH & CO KG; NEW IRIDIUM INC
摘要:The present invention relates to a process for coupling a heterocyclic aromatic ring AR1 and a carbocyclic or heterocyclic aromatic ring AR2 to each other by a light-assisted decarboxylative carbon-carbon cross-coupling reaction, whereinn a reaction medium is provided by mixing a first reactant, a second reactant and a catalyst composition, wherein the catalyst composition comprises (i) a palladium compound which is a palladium salt or a palladium complex or a mixture thereof, and (ii) a polycyclic compound of Formula (I), (II) or (III): nn n n n n n n n n n n n the reaction medium is irradiated by an external light source, thereby coupling the heterocyclic aromatic ring AR1 of the first reactant to the aromatic ring AR2 of the second reactant by a decarboxylative carbon-carbon cross-coupling reaction.

专利号:PT-89409-A
优先权日:1988-01-09
标题:PROCESS FOR THE PREPARATION OF NEW 3,5-DIHYDROXYCARBOXYL ACIDS AND THEIR DERIVATIVES, OF PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, AS WELL AS INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF THE NEW COMPOUNDS