CAS: 21907-50-6; Cesium Trifluoroacetate

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2923-16-2 31126-95-1 3336-58-1

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CAS号124-38-9 二氧化碳 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号431-47-0 三氟乙酸甲酯(TFAM) | CAS号76-05-1 三氟乙酸(TFA) | CAS号378-90-5 1,1,1,2,2,3,3,5...

三氟乙酸置于caesium Carbonate体系中,化学反应 0.25H,以96%的收率获得氧化汞红
参考文献:铜催化和无添加剂的芳族和杂芳族碘化物的脱羧三氟甲基化反应.
标题:铜催化和无添加剂的芳族和杂芳族碘化物的脱羧三氟甲基化反应.
摘要:已经开发了铜催化(杂)芳族碘化物的脱羧三氟甲基化.重要的是,这种新的铜催化反应在没有任何配体和金属添加剂的情况下进行.该协议显示出非常好的官能团耐受性,并且与杂芳族系统兼容.事实证明该反应可扩展至15 Mmol规模,且产率提高.最后,三氟甲基官能团的后期安装提供了抗抑郁药prozac的n-三氟乙酰胺变体,证明了所开发方法的适用性.
Doi:10.1039/c9Ob02635E

专利信息

专利号:US-5859288-A
优先权日:1995-03-24
标 题:Reagent and process for the synthesis of oxysulphide-containing fluorine-containing organic derivatives
发明人：FORAT GERARD; MAS JEAN-MANUEL; SAINT-JALMES LAURENT
权利人:RHONE POULENC CHIMIE
摘要:The invention relates to a reagent which is useful for the synthesis of oxysulphide-containing fluorine-containing organic derivatives by reacting with an oxide of sulphur, especially sulphur dioxide, characterized in that it comprises: a) a fluorocarboxylic acid of formula Ew-CF2-COOH where Ew is an electron-withdrawing group or atom which is at least partially salified by an organic or inorganic cation, and b) an aprotic polar solvent; and in that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid. This reagent can be used by heating in order to form fluorine-containing sulphinic or sulphonic acids.

专利号:WO-2006008493-A1
优先权日:2004-07-23
标 题 :Synthesis of polyhydroxylated alkaloids
发明人：NASH ROBERT JAMES; FLEET GEORGE WILLIAM JOHN; VAN AMEIJDE JEROEN; HORNE GRAEME
权利人:MNL PHARMA LTD; NASH ROBERT JAMES; FLEET GEORGE WILLIAM JOHN; VAN AMEIJDE JEROEN; HORNE GRAEME
摘要:A process for the production of a polyhydroxylated bicyclic (e.g. pyrrolizidine such as casuarine (10), indolizidine or quinolizidine) alkaloid comprises the cyclisation of a pyrrolidine or piperidine intermediate having three or more free hydroxyl groups.

专利号:US-8637274-B2
优先权日:2003-12-30
标题:Inhibitor for the formation of gamma-secretase complex
发明人：URANO YASUOMI; HAMAKUBO TAKAO; KODAMA TATSUHIKO
权利人:URANO YASUOMI; HAMAKUBO TAKAO; KODAMA TATSUHIKO; KOWA CO; NISSAN CHEMICAL IND LTD
摘要:It is intended to provide an inhibitor for the formation of a γ-secretase complex which comprises a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator as the active ingredient; and use of a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator for producing the same. It is also intended to provide a method of screening a substance having an effect of inhibiting the formation of an active complex of γ-secretase which comprises assaying the activity of inhibiting cholesterol synthesis or quantifying cholesterol accumulated in lipid rafts in cells. It is also intended to provide a method of screening a cholesterol synthesis inhibitor, a protein geranylgeranylation regulator or an HMG-CoA reductase inhibitor which comprises assaying the effect of inhibiting the formation of an active complex of γ-secretase. Moreover, it is intended to provide a method of screening an effect of a test substance on γ-secretase which comprises measuring the distribution of constituents (niscastrin, APH-1, Pen-2 and so on) required by γ-secretase for the formation of its active complex in cells.

专利号:US-2003215930-A1
优先权日:2000-12-08
标 题 :Genes involved in cyclododecanone degradation pathway
发明人：CHEN MARIO W; CHENG QIONG; GIBSON KATHARINE J; KOSTICHKA KRISTY N; THOMAS STUART M; NAGARAJAN VASANTHA
摘要:A 10 kb gene cluster has been isolated from Rhodococcus ruber SC1 comprising genes encoding enzymes useful for the synthesis of dodecanoic diacid from cyclododecanone and other cyclic intermediates. The six specific open reading frames have been identified that are associated with dodecanoic diacid biosynthesis. In addition to the expected substrates the enzymes of the instant invention have moderate specificity for C11-C15 compounds.

专利号:US-4268689-A
优先权日:1978-12-11
标 题 :Manufacture of vicinal glycol esters from synthesis gas
发明人：KNIFTON JOHN F
权利人:TEXACO DEVELOPMENT CORP
摘要:This invention concerns the improved preparation of glycol esters, such as ethylene glycol diesters, by reaction of carbon monoxide and hydrogen in the presence of a ruthenium or osmium-containing catalyst and a liquid phase medium containing a carboxylic acid co-reactant. The improvement which comprises the invention here also involves use of a co-catalyst species selected from the group consisting of one or more alkali metal salts, alkaline earth metal salts, quaternary ammonium salts, iminium salts and quaternary aliphatic phosphonium salts.

专利号:US-6464895-B2
优先权日:1995-03-24
标 题 :Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function
发明人：FORAT GERARD; MAS JEAN-MANUEL; SAINT-JALMES LAURENT
权利人:RHODIA CHIMIE SA
摘要:The invention relates to a nucleophilic reagent which is useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function, or for the synthesis of oxysulphide-containing and fluorine-containing organic derivatives, wherein said reagent comprises:a) a fluorocarboxylic acid of formula Ew-CF2-COOH where Ew represents an electron-withdrawing atom or group, at least partially salified with an organic or inorganic cation, andb) a polar aprotic solvent;and in that the content of releasable protons carried by its various components, including their impurities, is at most equal to half the initial molar concentration of the said fluorocarboxylic acid.A synthetic process uses this reagent by heating in order to graft a substituted difluoromethyl group onto various compounds.