CAS: 2363-59-9; Boldenone 17-Acetate

该化合物是一种具有1,4-dien-3-one结构特征的1,4-dien-3-1-one的血清化合物,其特征为1,4-dien-3-one结构,代之以17β-乙氧代氧,这种改变增强了其稳定性和生物利用率,使其成为合成有机化学和药物研究的宝贵中间体.17位置的乙氧基组提高了有机溶剂的溶解性,促进了进一步的化学转化.1,4位置的同源狄纳系统为选择性功能化提供了再活性,在类固醇衍生过程中有用.其结构特征使其适合用于与激素有关的研究和研制抗血清药物.该化合物通常在受控制的条件下处理,因为它对光和湿度敏感.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号1045-69-8 醋酸睾酮 | CAS号58-22-0 睾酮 | CAS号82926-51-0 17β-acetoxy-2β,... | CAS号1164-92-7 Androstan-3-one... | CAS号15359-18-9 17β-Acetoxy-3-o... | CAS号108-24-7 乙酸酐 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号108-75-8 2,4,6-三甲基吡啶 | CAS号1045-69-8 醋酸睾酮

合成工艺路线路线简述

    醋酸睾酮置于thallium(III) Acetate体系中,用 溶剂黄146 用作溶剂,化学反应生成17-乙酸勃地酮
    参考文献:Romeo,A.; Ortar,G.,Tetrahedron,1972,Vol. 28,P. 5338-5339
    标题:Romeo,A.; Ortar,G.,Tetrahedron,1972,Vol. 28,P. 5338-5339

    海关参考信息

    专利信息


    专利号:US-5908944-A
    优先权日:1991-09-27
    标题 :Methylation or ethylation agent and process for 1,4-addition of a methyl or ethyl group to an α, β-unsaturated keto compound
    发明人:WESTERMANN JUERGEN; NICKISCH KLAUS
    权利人:SCHERING AG
    摘要:This invention describes a new methylation or ethylation agent containing trimethyl aluminum or dimethyl zinc or triethyl aluminum as methyl or ethyl source, which additionally contains catalytic amounts of one or more copper(I) and/or copper(II) compounds as well as a process for the 1,4-addition of a methyl or ethyl group to an α,β-unsaturated or an α,β-double unsaturated ketone or an α,β-unsaturated aldehyde using the agent according to the invention. n By using only catalytic amounts of copper and a CKW (chlorinatedhydrocarbon)-free reaction medium, the new methylation/ethylation agent/process is distinguished by its environmental compatibility and it is, for example, suitable for the production of initial products for the synthesis of biologically effective compounds.

    专利号:US-2025281509-A1
    优先权日:2021-04-26
    标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer
    发明人:DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER
    权利人:UNIV JOHNS HOPKINS
    摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.
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    主要参考文献

    参考标题:Methylation Or Ethylation Agent And Process For 1,4-Addition Of A Methyl
    摘要:This Invention Describes A New Methylation Or Ethylation Agent Containing Trimethyl Aluminum Or Dimethyl Zinc Or Triethyl Aluminum As Methyl Or Ethyl Source, Which Additionally Contains Catalytic Amounts Of One Or More Copper(I) And/or Copper(II) Compounds As Well As A Process For The 1,4-Addition Of A Methyl Or Ethyl Group To An .Alpha.,.Beta.-Unsaturated Or An .Alpha.,.Beta.-Double Unsaturated Ketone Or An .Alpha.,.Beta.-Unsaturated Aldehyde Using The Agent According To The Invention. By Using Only Catalytic Amounts Of Copper And A Ckw (Chlorinatedhydrocarbon)-Free Reaction Medium, The New Methylation/ethylation Agent/process Is Distinguished By Its Environmental Compatibility And It Is, For Example, Suitable For The Production Of Initial Products For The Synthesis Of Biologically Effective Compounds.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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