CAS: 23964-58-1; Methyl 4-Methyl-3-[2-(Propylamino)Propanoylamino]Thiophene-2-Carboxylate

Methyl 3-Methyl-1-Oxo-4-[2-(Propylamino)Propanoylamino]-2,3-Dihydrothiophene-5-Carboxylate 反应生成阿替卡因
参考文献:Rippel,Robert;Flemming,Hans-Wolfram;Rukwied,Manfred
标题:Rippel,Robert;Flemming,Hans-Wolfram;Rukwied,Manfred

专利信息

专利号:EP-1776333-B1
优先权日:2004-07-21
标 题:Ammonium salts and ammonium salt/mineral salt clathrate compounds for use as vehicle and effective form for pharmaco-medical applications and for use as phase transfer agents for chemical applications
发明人：REUTER UWE; OETTMEIER RALF; KASCH HELMUT
权利人:KASCH HELMUT
摘要:This invention relates to ammonium salts and stable storable ammonium salts and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues such as bicarbonate, to methods for producing them and to pharmaco-medical and chemical synthetic applications for said compounds. According to the invention, compounds for pharmaco-medical and chemical synthetic applications are produced which comprise the ammonium salt and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues of general formula I with R1, R2, R3 and R4=alkyl and substituted alkyl straight-chain or branched, optionally having an alcohol, ether, silyether, ester, amino or amide function, H or aryl-alkyl, with aryl being an aromatic or heteroaromatic ring having optionally additional substituents, such as alkyl having 1 to 4 C atoms, OH, NR*2 with R*2=O, alkyl with alkyl of between 1 and 4 C atoms or H, COOH, COOR, CN, NO2 and the cationic positive N+ is optionally part of an active agent, Y is a dibasic acid residue of an organic dicarboxylic acid or CO3-, corresponding to HY-=HCO3-, and x=0.5 to 30 represents the number of the mineral salt molecules for clathrate compound formation or 0. In pharmaco-medical applications applies the generalizable effectiveness principle according to which to ammonium salt/mineral salt cluster is used as vehicle and active agent for novel forms of application of nitrogen-containing active agent bases. In chemistry, these agents are used in the synthesis of active agents and valuable products, e.g. of cyclic carbonates.

专利号:RU-2184730-C1
优先权日:2001-05-16
标 题 :Method of synthesis of 4-methyl-3-[2-(n-propyl- -amino)propionylamino]thiophene-2-carboxylic acid methyl ester hydrochloride

专利号:CN-216856707-U
优先权日:2022-01-13
标 题:A kind of condensation cooling system for the synthesis of articaine intermediate

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.

专利号:US-2024091199-A1
优先权日:2017-06-30
标 题:Deuterated Domperidone Compositions, Methods, and Preparation
发明人：PEARCE CATHERINE; ISAACSOHN JON; PATEL PIYUSH
权利人:CINDOME PHARMA INC
摘要:Deuterated domperidone compositions, methods of synthesis, methods of use, and dosing formulations providing beneficial safety and other effects.

专利号:US-2007148246-A1
优先权日:2005-08-11
标题:Nucleic Acid-Based Matrixes
发明人：LUO DAN; LI YOUGEN
权利人:LUO DAN; LI YOUGEN
摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.