溶剂紫9置于盐酸体系中,化学反应生成 龙胆紫 参考文献:Biddle; Porter,Journal Of The American Chemical Society,1915,Vol. 37,P. 1575,1579,1585 标题:Biddle; Porter,Journal Of The American Chemical Society,1915,Vol. 37,P. 1575,1579,1585
专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10150160-B2 优先权日:2014-12-04 标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles 发明人:PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT 权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A 摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.
专利号:US-4774173-A 优先权日:1984-12-06 标 题 :Microbiological assay kit and method for detecting de novo biomolecular synthesis inhibitors 发明人:REINHARTZ AVRAHAM 权利人:ORGENICS LTD 摘要:A method for assaying a specimen for the presence of a substance capable of inhibiting de novo biomolecular synthesis in a test microorganism, which comprises: exposing a cell wall permeability-enhanced test microorganism exhibiting delayed de novo synthesis of said biomolecule to said specimen, and assaying the extent of inhibition of synthesis of said biomolecule in said microorganism. A kit is described for performing the method, as well as a reaction mixture for performing the technique.
专利号:US-8722881-B2 优先权日:2009-10-13 标题 :Method of synthesis of tetradentate amide macrocycle ligand and its metal-complex 发明人:GHOSH ANINDYA; SULLIVAN SHANE Z; COLLOM SAMUEL L; PULLA SHARON 权利人:GHOSH ANINDYA; SULLIVAN SHANE Z; COLLOM SAMUEL L; PULLA SHARON; UNIV ARKANSAS 摘要:A tetradendate amide based macrocyclic ligand and its Fe(III) complex which act as activators of hydrogen peroxide. The synthetic methodology to develop the ligands is new, simple and provides better yield for each step of the ligand synthesis. The Fe(III)-complexes and hydrogen peroxide together are can perform several environmentally benign oxidation reactions. Organic dye bleaching, bleaching of pulp and paper effluent and N-oxide synthesis may be performed using the newly developed catalyst and hydrogen peroxide. Alcohol oxidation and alkene epoxidation may also be performed using the catalysts and hydrogen peroxide.
专利号:US-10323010-B2 优先权日:2015-07-20 标题 :Methods of chemical synthesis of substituted 10H-phenothiazine-3,7-diamine compounds 发明人:STOREY JOHN MERVYN DAVID; LARCH CHRISTOPHER PAUL; KEMP STEVEN JOHN; CLUNAS SCOTT; NICOLL SARAH LOUISE; GIBBARD HELEN SARAH; SIMPSON MICHAEL; SINCLAIR JAMES PETER; MARSHALL COLIN 权利人:WISTA LAB LTD 摘要:The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.
专利号:US-4585640-A 优先权日:1984-11-16 标题:Synthesis of molecular sieving high silica mordenite using synthesis directing organic dyes 发明人:DESMOND MICHAEL J; PESA FREDERICK A; CURRIE JANIE K 权利人:STANDARD OIL CO OHIO 摘要:A method is disclosed for making molecular sieving high silica mordenite comprising the steps of: (A) providing a mixture comprising: water; an oxide of silicon source; an oxide of aluminum source; a mineralizing agent; and a synthesis directing nitrogen containing organic dye; and (B) maintaining said mixture at a temperature of about 80 DEG C. to about 300 DEG C. for an effective period of time to provide said mordenite.
参考文献:10.1007/s10549-010-0765-7 摘要:Di X, Gennings C, Bear HD, Graham LJ, Sheth CM, White KL, Gewirtz DA. Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Research and Treatment. 2010 Feb 13;124(2):349–60. doi: 10.1007/s10549-010-0765-7. 参考文献:10.1007/s11596-010-0104-6 摘要:Zheng W, Wan Y, Ma X, Li X, Yang Z, Yin Q, Yi J. Isolation of cultured endothelial progenitor cells in vitro from PBMCs and CD133(+) enriched cells. J Huazhong Univ Sci Technolog Med Sci. 2010 Feb;30(1):18–24. doi: 10.1007/s11596-010-0104-6. 参考文献:10.1007/s00280-009-1233-0 摘要:Antoon JW, Liu J, Ponnapakkam AP, Gestaut MM, Foroozesh M, Beckman BS. Novel D: -erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics. Cancer Chemother Pharmacol. 2010 May;65(6):1191–5. doi: 10.1007/s00280-009-1233-0. 参考文献:10.1007/s10549-010-0786-2 摘要:Park SK, Sanders BG, Kline K. Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling. Breast Cancer Research and Treatment. 2010 Feb 16;124(2):361–75. doi: 10.1007/s10549-010-0786-2.