CAS: 59337-92-7; Methyl 3-(Chlorosulfonyl)Thiophene-2-Carboxylate

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CAS号59337-91-6 3-chlorosulfony... | CAS号67-56-1 甲醇 | CAS号22288-78-4 3-氨基-2-噻吩甲酸甲酯 | CAS号59337-89-2 3-氯噻吩-2-羧酸 | CAS号59337-93-8 3-(氨基磺酰基)噻吩-2-羧酸甲酯 | CAS号145865-81-2 methyl 3-[[(E)-... | CAS号145865-78-7 methyl 3-[(benz... | CAS号184040-74-2 3-(N-(4-氯-3-甲基异... | CAS号210421-71-9 3-(N-(4-氯-3-甲基异... | CAS号184644-72-2 3-{[(4-氯-3-甲基-5... | CAS号98827-44-2 替诺昔康环合物 | CAS号59804-37-4 替诺昔康 | CAS号59804-25-0 替诺昔康甲化物 | CAS号106820-63-7 3-磺酰氨基乙酸甲酯-2-噻吩甲酸甲酯

3-氯噻吩-2-羧酸置于sodium Hydroxide,五氯化磷,Potassium Chloride,Sodium Hydrogensulfite,Copper(L) Chloride,三氯氧磷体系中,用 氯仿,水 作为反应溶剂,化学反应 20.5H,反应生成 3-氯磺酰基-2-噻吩甲酸甲酯
参考文献:Analogs And Derivatives Of Tenoxicam. 1. Synthesis And Antiinflammatory Activities Of Analogs With Different Residues On The Ring Nitrogen And The Amide Nitrogen
标题:Analogs And Derivatives Of Tenoxicam. 1. Synthesis And Antiinflammatory Activities Of Analogs With Different Residues On The Ring Nitrogen And The Amide Nitrogen
摘要:The Synthesis Of Tenoxicam,4-Hydroxy-2-Methyl-N-2-Pyridyl-2H-Thieno[2,3-E]-1,2-Thiazine-3-Carboxami De 1,1-Dioxide (1E),And Of The Analogues With Various Residues On The Ring Nitrogen And The Amide Nitrogen Is Described. This New Class Of "Oxicams" Has Pronounced Antiinflammatory And Analgesic Properties. The Very Specific Structure-Activity Relationship Of Isomeric And Isosteric Groups At The Amide Nitrogen Has Been Evaluated. The Substituent In Position 2 Also Has A Great Influence On The Pharmacological Properties. Tenoxicam Is Presently Undergoing Clinical Trials.
DOI:10.1021/jm00387A017

专利信息

专利号:US-4143050-A
优先权日:1977-01-05
标题 :Manufacture of 3-halosulfonylthiophene-carboxylic acid compounds
发明人：ROSSY PHILLIP A; HOFFMANN WERNER; MUELLER NORBERT
权利人:BASF AG
摘要:3-Halosulfonylthiophene-carboxylic acid compounds are manufactured by reacting 3-ketothiophane-carboxylic acid compounds with sulfonic acid compounds, reacting the end product from the 1st reaction stage with alkali metal polysulfides, reacting the end product from the 2nd stage with a dehydrogenating agent and finally reacting the end product from the 3rd stage with halogen and water. The products are starting compounds for the manufacture of drugs, dyes and crop protection agents and have an anti-inflammatory, analgesic and anti-rheumatic action. In particular, the end products I are starting materials for the manufacture of sweeteners which are non-toxic and free from an after-taste, flavor-improving agents, diabetic aids and feedstuffs, and provide the means of a simple and economical synthesis of thiophene-saccharins.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2020216836-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries

专利号:EP-1957644-B1
优先权日:2005-12-01
标 题 :Enzymatic encoding methods for efficient synthesis of large libraries