CAS: 611-09-6; 5-Nitroindoline-2,3-Dione

上下游产品

CAS号91-56-5 靛红 | CAS号17122-62-2 2-羟基亚氨基-N-(4-硝基... | CAS号6146-52-7 5-硝基吲哚 | CAS号79-37-8 草酰氯 | CAS号100-01-6 对硝基苯胺 | CAS号302-17-0 水合氯醛 | CAS号16135-31-2 N-(4-硝基苯基)甲酰胺 | CAS号113423-47-5 3,3-dibromo-4-n... | CAS号42366-35-8 (2E)-2-(Hydroxy... | CAS号141046-95-9 N-methyl-5-nitr... | CAS号39263-34-8 N'-(2-氰基-4-硝基苯基... | CAS号42816-53-5 5-氨基靛红 | CAS号184356-50-1 N-(3-氯-4-氟苯基)-6... | CAS号96-97-9 5-硝基水杨酸 | CAS号78155-76-7 5-硝基吲唑-3-羧酸 | CAS号5398-27-6 2,6-二碘-4-硝基苯胺 | CAS号616-79-5 2-氨基-5-硝基苯甲酸 | CAS号3484-32-0 1-甲基-5-硝基靛红 | CAS号4693-02-1 5-硝基靛红酸酐

靛红置于sodium Nitrate,硫酸体系中,化学反应 1.0H,以91%的收率获得产物5-硝基靛红
参考文献:作为 Src 酪氨酸激酶抑制剂的新型 1,3,5-取代的 Indolin-2-One 衍生物的合成,生物学和计算评价
标题:作为 Src 酪氨酸激酶抑制剂的新型 1,3,5-取代的 Indolin-2-One 衍生物的合成,生物学和计算评价
摘要:合成了几种取代的 Indolin-2-One 衍生物并评估了它们对 Src 激酶的活性.几种化合物显示出对 Src 的活性,Ic50 值在低微摩尔范围内.其中,化合物2F显示出最显着的活性,Ic50值为1.02 μm.已进行分子对接研究以评估化合物 2F 与 Src 活性位点的结合模式.化合物2F的对接结构揭示了吲哚nh与met341的羰基形成氢键.这些结果表明,我们的新型化合物 2F 是一种有前途的化合物,可用于进一步开发靶向 Src 激酶的吲哚类药物.
DOI:10.1002/ardp.201500109

专利信息

专利号:US-2011263540-A1
优先权日:2008-07-25
标题 :Small-molecule inhibitors of protein synthesis inactivating toxins
发明人：PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-8497296-B2
优先权日:2011-03-31
标 题:N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
发明人：HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER
权利人:HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER; UNIV KING SAUD
摘要:The invention is directed to a compound of Formula (I), n nwherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R 1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C 1 -C 4 alkyl group, nitro group, and —OCF 3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.

专利号:US-8933248-B2
优先权日:2012-06-21
标 题:3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
发明人：RAO MANDAPATI MOHAN; PRATHIMA PARVATHANENI SAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II).

专利号:US-7149280-B2
优先权日:2002-12-23
标 题 :Synthesis and screening of ligands using X-ray crystallography
发明人：JHOTI HARREN; CONGREVE MILES STUART; O'REILLY MARC; WYATT PAUL GRAHAM
权利人:ASTEX THERAPEUTICS LTD
摘要:A method for identifying a ligand of a target macromolecule is disclosed, comprising the steps of: soaking one or more crystals of the target macromolecule in a solution containing a collection of compounds generated in situ or separate from the crystal, where the solution has been prepared without the purification of the synthesized collection of compounds; obtaining an X-ray crystal diffraction pattern of the soaked macromolecule crystal; and using said X-ray crystal diffraction pattern to identify any compound bound to the macromolecule crystal, said compound being a ligand of the target macromolecule.

专利号:CN-114805353-A
优先权日:2022-01-11
标题:Synthesis of azatryptanthrin derivative and application of azatryptanthrin derivative in prevention and treatment of plant pathogenic bacteria, fungi bactericide and anti-plant virus preparation