CAS: 705-15-7; 2'-Hydroxy-5'-Methoxyacetophenone

上下游产品

4-methoxyphenyl acetate acetic acid 1,4-dimethoxybezene acetyl chloride 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester trans-chalcone2'-hydroxy-5'-methoxy-2,5-bis-methoxymethoxy-trans-chalcone trans-chalcone2'-hydroxy-3,5'-dimethoxy-4-methoxymethoxy-trans-chalcone trans-chalcone2'-hydroxy-5'-methoxy-2-methoxymethoxy-trans-chalcone

2,5-二羟基苯乙酮置于碘甲烷体系中,用 丙酮 作为反应溶剂,化学反应 12.0H,反应生成 2'-羟基-5'-甲氧基苯乙酮
参考文献:Chalcones和aurones作为选择性mao-B抑制剂的合成,生物学评估和分子模拟
标题:Chalcones和aurones作为选择性mao-B抑制剂的合成,生物学评估和分子模拟
摘要:合成了一系列查耳酮和金酮,并在体外作为单胺氧化酶抑制剂(maoi)进行了评估.我们的结果表明,以前未被报道为maoi的金环是mao-B抑制剂.因此,两个家族选择性地抑制了微摩尔范围内的mao的b同工型,为设计新型和有效的mao抑制剂提供了新颖的支架.借助3D-Qsar和对接研究来表征其活动的主要结构要求.
DOI:10.1111/cbdd.12458

专利信息

专利号:US-7741484-B2
优先权日:2005-09-01
标 题 :Process for synthesis of phenoxy diaminopyrimidine derivatives
发明人：CONSTANTINESCU ANTON; GREEN KEENA LYNN; HUMPHREYS ERIC ROY; LEE GARY R; MCGARRY PATRICK FINBAR
权利人:ROCHE PALO ALTO LLC
摘要:A method for preparing a compound of formula I n nthe method comprising treating a compound of formula dn n nwith an iodination reagent, to form the compound of formula I, wherein R 1 , R 2 and R 3 are as defined herein.

专利号:US-9643934-B2
优先权日:2006-10-04
标 题:Process for synthesis of phenoxy diaminopyrimidine derivatives
发明人：DVORAK CHARLES ALOIS; GREEN KEENA LYNN; LEE GARY R
权利人:ROCHE PALO ALTO LLC
摘要:A method for preparing a compound of formula k n n n n n n n n n n n n or a salt or solvate thereof,n wherein R 1 is as defined herein, n n the method comprising treating a compound of formula j n n n n n n n n n n n n n n n n or a salt or solvate thereof, n with ammonia, to form the compound of formula k.

专利号:US-9321804-B2
优先权日:2011-03-09
标题 :Synthesis and use of anti-tumor drug LQC-Y
发明人：LEI HAIMIN
权利人:UNIV BEIJING CHINESE MEDICINE; 3D MEDICINES LTD
摘要:Disclosed are the general structural formula of LQC-Y as well as the synthesis and use thereof. Pharmacological experiments demonstrated the marked antitumor effect of such compounds. Single day administration of LQC-Y3 to mice at a maximum dose of 6000 mg/kg showed no toxicity response during the 14-day continuous observation period, indicating the high safety of the compounds, and the compounds can be used to prepare medicaments for preventing and treating carcinomas such as liver cancer, lung cancer. In the general structural formula of LQC-Y, R represents steroid compounds such as cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, and hyodeoxycholic acid and so on; triterpenoid compounds such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides thereof and so on; emodic acid, emodin and other mono-substituted or poly-substituted structures of anthraquinone parent nucleus; baicalein, baicalin and other flavonoid; shikimic acid, mono-substituted shikimic acid or poly-substituted shikimic acid; gardenia acid and other iridoid acid derivatives; paeonol, curcumin and structural derivatives thereof.

专利号:US-2007049751-A1
优先权日:2005-09-01
标 题 :Process for synthesis of phenoxy diaminopyrimidine derivatives

专利号:US-8580960-B2
优先权日:2006-10-04
标题:Process for synthesis of phenoxy diaminopyrimidine derivatives

专利号:US-2008086004-A1
优先权日:2006-10-04
标题 :Process for synthesis of phenoxy diaminopyrimidine derivatives