CAS: 7144-08-3; Cholesteryl Chloroformate

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CAS号32315-10-9 三光气 | CAS号57-88-5 胆固醇 | CAS号75-44-5 光气 | CAS号1449331-30-9 (8R,9R,10S,13S,... | CAS号57-88-5 胆固醇 | CAS号3264-21-9 1-乙酰基芘 | CAS号23836-43-3 胆固醇乙基碳酸酯 | CAS号2665-02-3 [10,13-dimethyl... | CAS号33985-07-8 胆固醇2-丙炔基-1-YL碳酸酯 | CAS号29331-39-3 胆甾烯基碳酸酯 | CAS号7510-04-5 胆固醇苯胺 | CAS号92588-72-2 [(3S,8S,9S,10R,... | CAS号6107-26-2 5-bromo-N-[(4-p...

(8R,9R,10S,13S,14R,17S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-10,13-Dimethyl-17-((S)-6-Methylheptan-2-yl)-1H-Cyclopenta[a]Phenanthren-3-Yl 2-Oxo-2-(Pyren-1-yl)Ethyl Carbonate置于水,Sodium Carbonate体系中,用 甲苯,乙腈 作为反应溶剂,化学反应 6.0H,反应生成 胆固醇甲酰氯
参考文献:1-(羟基乙酰基)py是一种新型荧光光触发装置,用于细胞成像和笼罩酒精,苯酚和腺苷†
标题:1-(羟基乙酰基)py是一种新型荧光光触发装置,用于细胞成像和笼罩酒精,苯酚和腺苷†
摘要:1-(羟基乙酰基)py作为一种用于醇和酚的新型荧光光触发剂,已被引入.通过与荧光光触发偶合,将醇和酚作为相应的碳酸酯进行保护,1-(羟乙酰基)py.笼状碳酸盐的光物理研究表明,它们都具有很强的荧光特性.水溶液中可见光(>=410Nm)辐照笼状碳酸盐乙腈以高化学产率(95-97%)和量子产率(0.17-0.21)释放了相应的醇或酚.基于stern-Volmer猝灭实验和溶剂效应研究,提出了光致释放的机理.重要的,1-(羟乙酰基)py 显示为光触发可快速释放生物活性分子 腺苷.体外生物学研究表明1-(羟乙酰基)py 具有非常好的生物相容性,细胞摄取特性和细胞成像能力.
DOI:10.1039/c2Pp25091H

专利信息

专利号:US-5571677-A
优先权日:1993-07-02
标题:Convergent synthesis of branched and multiply connected macromomolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which.complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:US-5830658-A
优先权日:1995-05-31
标 题 :Convergent synthesis of branched and multiply connected macromolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-6180777-B1
优先权日:1996-01-12
标 题 :Synthesis of branched nucleic acids
发明人：HORN THOMAS
权利人:BAYER AG
摘要:Branched polymers and multiply connected macromolecular structures are provided, wherein the polymers and structures are provided, wherein the polymers are structures comprise at least two branches and/or macrocycles, at least one of which is a target binding moiety capable of binding to a target molecule of interest, and at least another of which is a signal generation moiety capable of directly or indirectly generating a signal. These polymers and structures contain components that are linked through sulfur-containing bridges that are selectively cleaved by oxidation, e.g. thiophosphorylacyl, dithiophosphorylacyl, thiophosphorylthio, thiophosphorylalkylamino and/or dithiophosphorylalkylamino bridges, Synthetic methods are also provided, as are kits containing a complexing buffer and a nucleic acid probe composed of the branched polymer or macromolecular structure.

专利号:US-6001991-A
优先权日:1996-10-04
标题 :Antisense oligonucleotide modulation of MDR P-glycoprotein gene expression
发明人：DEAN NICHOLAS M; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding the human MDR1 P-glycoprotein. Also disclosed are methods of using the oligonucleotides of the invention in methods of modulating the expression of MDR genes, inhibition of which leads to inhibition of the synthesis of MDR P-glycoproteins and thereby inhibits cellular multidrug resistance. Such inhibition is desirable for treating various hyperproliferative disorders or diseases, such as various cancers, in conjunction with chemotherapy utilizing one or more chemotherapeutic agents, for preventing or modulating the development of multidrug resistance during the chemotherapeutic treatment of an animal, and for resensitizing hyperproliferative MDR cells in an animal having such diseases or disorders that has been previously exposed to chemotherapeutic agents. Modified derivatives of the oligonucleotides of the invention, such as chimeras and conjugates (e.g., of an oligonucleotide and a lipophilic moiety, such as cholesterol), are also disclosed. The biological activity and cellular uptake of oligonucleotides is enhanced by such modifications.

专利号:US-7361731-B2
优先权日:2002-05-20
标 题:Peptide derivatives, and their use for the synthesis of silicon-based composite materials
发明人：MCAULIFFE JOSEPH C; BOND RISHA LINDIG; CUEVAS WILLIAM ALBERT
权利人:GENENCOR INT
摘要:Methods for forming peptide derivatives using functional moieties and peptide derivatives are provided. Further, methods for using peptide derivatives to form silicon-based composite materials and silicon-based composite materials formed thereby are provided. The silicon-based composite materials may have features on the nanoscale, and the materials may exhibit characteristics derived from the functional moieties on the peptide derivatives. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.