CAS: 886-86-2; Ethyl 3-Aminobenzoate Methanesulfonate

在 氢气体系中,用 甲醇 作为反应溶剂,80.0~90.0 °C,1.18 Mpa 条件下,反应生成 3-氨基苯甲酸乙酯甲基磺酸盐
参考文献:奥沙拉嗪钠工艺开发过程中异常杂质的形成导致甲磺酸三卡因的高效,经济合成
标题:奥沙拉嗪钠工艺开发过程中异常杂质的形成导致甲磺酸三卡因的高效,经济合成
摘要:本文报道了奥沙拉嗪钠 Api 合成过程中硝基还原过程中形成的杂质,后来为开发甲磺酸三卡因的短而高效的生产工艺而进行了探索.该合成的亮点是,在硝基还原过程中,发生脱氧反应,形成三卡因核心,而留下的甲磺氧基作为抗衡阴离子,一步形成甲磺酸三卡因.这里报道的方法避免了分离游离碱和单独的盐形成步骤的需要,因此更加经济和有效.
DOI:10.1002/jhet.4645

专利信息

专利号:US-2006111369-A1
优先权日:2004-11-10
标 题:Synthesis, characterization and biological action of optically active isomers of floxacins
发明人：SOMBERG JOHN C; RANADE VASANT V
权利人:SOMBERG JOHN C; RANADE VASANT V
摘要:Disclosed herein is the method for synthesis and separation of enantiospecific isomers of floxacins. These isomers can be used to study the antibacterial action, as well as cardiac effects, such as arrhythmogenic activity, QT internal prolongation and dispersion, and Ikr inhibition in humans. A method for the identification of chiral isolates of the floxacins that are devoid or possess less QT prolonging action and thus cause less arthropathy especially of the Torsades de pointes variety. Also disclosed are methods for assaying these isomeric compounds present in the biological fluids.

专利号:US-2009011447-A1
优先权日:2006-05-25
标题 :Quantification of vitellogenin
发明人：BANOUB JOSEPH H; COHEN ALEJANDRO; MANSOUR ATEF
权利人:BANOUB JOSEPH H; COHEN ALEJANDRO; MANSOUR ATEF
摘要:The present invention is directed to a simple method for absolute quantification of plasma vitellogenin from two or more different fish species such as Rainbow trout and Atlantic salmon, or Atlantic cod and haddock. In the case of Rainbow trout and Atlantic salmon, plasma samples obtained from control and β-estradiol induced fish were digested with trypsin. A characteristic ‘signature peptide’ was selected and analyzed by high performance liquid chromatography coupled to an electrospray quadrupole-time-of-flight tandem mass spectrometer, using a deuterated homologue peptide as an internal standard. The hybrid tandem mass spectrometer was operated in a ‘pseudo’ selected reaction monitoring mode by which three diagnostic product ions were monitored for identification and quantification purposes. The reproducibility (coefficient of variation Ëœ5%) and sensitivity (limit of quantification of 0.009 mg/mL) achieved by this simple assay allow it to be considered as an alternative to immunological assays. In the case of Atlantic cod and haddock, the amino acid sequence of the vitellogenin protein has not yet been determined, but, the Atlantic cod vitellogenin has been characterized using a ‘bottom-up’ mass spectrometric approach. Vitellogenin synthesis was induced ‘in vivo’ with β-Estradiol, and subjected to trypsin digestion for characterization by matrix-assisted laser desorption/ionization-Quadrupole-Time-of-flight tandem mass spectrometry. A peptide mass fingerprint was obtained and ‘de novo’ sequencing of the most abundant tryptic peptides was performed by low energy collision induced dissociation-tandem mass spectrometry. Thus, the sequences of various tryptic peptides have been elucidated. It has also been determined that Atlantic cod vitellogenin shares a series of common peptides with the two different known vitellogenin sequences of Haddock, a closely related species. There are also disclosed novel isolated signature peptides, namely Thr-Tyr-Phe-Ala-Gly-Ala-Ala-Ala-Asp-Val-Leu-Glu-Val-Gly-Val-Arg, Asp Leu Gly Leu Ala Tyr Thr Glu Lys, Phe Phe Gly Gln Glu Ile Ala Asn Ile Asp Lys, Glu Ile Val Leu Leu Gly Tyr Gly Thr Met Ile Ser Lys and Tyr Glu Ser Phe Ala Val Ala Arg.

专利号:WO-2012107073-A1
优先权日:2011-02-07
标题 :Ubiad1 for cellular coenzyme q10 synthesis and cardiovascular oxidative protection
发明人：SANTORO MASSIMO
权利人:SANTORO MASSIMO
摘要:The present invention concerns the field of antioxidants. In particular the invention concerns prenyltransferases, for enhancing the production of Coenzyme Q10. The invention further regards the use of prenyltransferases in the treatment of diseases that result from oxidative stress and their use in the field of cosmetics.

专利号:US-5538993-A
优先权日:1991-09-12
标题 :Certain tetrahydrocannabinol-7-oic acid derivatives
发明人：MECHOULAM RAPHAEL; BREUER AVIVA; DEVANE WILLIAM; BURSTEIN SUMNER H
权利人:YISSUM RES DEV CO
摘要:The invention relates to compounds of the formula (I) having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, in which A-B indicates an optional 1(2) or 6(1) double bond, X is carboxy, carbalkoxy, or carboxamido, linked to the ring directly or through an alkylene linkage, G is halogen, alkyl, or oxy, and Y is alkyl, oxy, or oxyalkylene. The invention further relates to the synthesis of such compounds, and to pharmaceutical compositions and therapeutic methods in which such compounds may be employed.

专利号:WO-2006052264-A2
优先权日:2004-11-10
标 题:Synthesis, characterization and biological action of optically active isomers of floxacins

专利号:CN-114716337-A
优先权日:2022-05-14
标 题 :A kind of synthesis technology of high-purity, high-yield trimethaine