CAS: 101349-71-7; 4-Chloro-3-Methylbenzaldehyde

相似化合物

7697-29-2 4387-31-9 91367-05-4

上下游产品

hexamethylenetetramine 4-(bromomethyl)-1-chloro-2-methylbenzene 2-chloro-5-bromotoluene N,N-dimethyl-formamide 4-chloro-3-methylbenzoic acid [1-(4-Chloro-3-methyl-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine 2-(4-Chloro-3-methyl-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol N-[(4-chloro-3-methyl-phenyl)-(toluene-4-sulfonyl)methyl]formamide

2-甲基-2-丁烯腈置于三氯氧磷体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,以21%的收率获得4-氯-3-甲基苯甲醛
参考文献:具有wnt信号通路抑制活性的杂环化合物及其应用
标题:具有wnt信号通路抑制活性的杂环化合物及其应用
摘要:本发明提供了一种具有wnt信号通路抑制活性的杂环化合物.该杂环化合物及其药学上可接受的盐,同位素,异构体和晶型结构,具有通式i所示的结构:(I).本发明还提供上述的具有wnt信号通路抑制活性的杂环化合物的应用.本发明的具有wnt信号通路抑制活性的杂环化合物,作为wnt信号通路的有效拮抗剂,能够用于治疗或预防因wnt信号通路失常引起的病症.

专利信息

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.