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CAS号58-61-7 腺苷

L-Adenosine置于f. Falciparum Ada体系中,用 Phosphate Buffer 用作溶剂,化学反应生成L-肌苷
参考文献:L-Nucleoside Analogues As Potential Antimalarials That Selectively Targetplasmodium Falclparumadenosine Deaminase
标题:L-Nucleoside Analogues As Potential Antimalarials That Selectively Targetplasmodium Falclparumadenosine Deaminase
摘要:The L-Stereoisomer Analogues Of D-Coformycin Selectively Inhibited P. Falciparum Adenosine Deaminase (Ada) In The Picomolar Range (L-Isocoformycin,K-I 7 Pm; L-Coformycin,K-I 250 Pm). While The L-Nucleoside Analogues,L-Adenosine,2,6-Diamino-9-(L-Ribofuranosyl)Purine And 4-Amino-1-(L-Ribofuranosyl)Pyrazolo [3,4-D]-Pyrimidine Were Selectively Deaminated By P. Falciparum Ada,L-Thioinosine And L-Thioguanosine Were Not. This Is The First Example Of 'Non-Physiological' L-Nucleosides That Serve As Either Substrates Or Inhibitors Of Malarial Ada And Are Not Utilised By Mammalian Ada.
Doi:10.1080/07328319908044624