CAS: 22282-96-8; 2-Bromo-6-Methyl-5-Nitropyridine

相似化合物

126325-47-1 18699-87-1 911434-05-4

上下游产品

6-methyl-5-nitropyridin-2-ol (1H-pyrrolo[3,2-b]pyridin-5-yl)methanamine 2-(6-bromo-3-nitropyridin-2-yl)-1-(2-chloro-6-fluorophenyl)ethanone 5-bromo-2-(2-chloro-6-fluorophenyl)-1H-pyrrolo[3,2-b]pyridine 2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine

2-羟基-5-硝基-6-甲基吡啶置于三溴氧磷体系中,用 1,1,2,2-四氯乙烷 用作溶剂,化学反应 4.0H,反应生成2-溴-5-硝基-6-甲基吡啶
参考文献:Azaindoles: Moderately Basic P1 Groups For Enhancing The Selectivity Of Thrombin Inhibitors
标题:Azaindoles: Moderately Basic P1 Groups For Enhancing The Selectivity Of Thrombin Inhibitors
摘要:Starting From A 2-Amino-6-Methylpyridine Pi Group And Following A Strategy Of Enlarging It Whilst Reducing Its Polarity,We Have Developed A Series Of Potent,Moderately Basic Azaindoles Which Are Intrinsically Much More Selective For Thrombin Versus Trypsin. Certain Pyrazinone Acetamide Azaindole Derivatives Have Pharmacokinetic Parameters After Oral Administration To Dogs,Or Efficacy In Vitro,Comparable To An Optimized Pyrazinone Acetamide 2-Amino-6-Methylpyridine Derivative. (C) 2003 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0960-894X(03)00017-9