CAS: 22536-65-8; 2-Chloro-5-Methoxypyrimidine

相似化合物

82153-68-2 1192813-64-1 4983-28-2

上下游产品

2,4-dichloro-5-methoxypyrimidine 5-Methoxypyrimidine-2,4(1H,3H)-dione 2-chloropyrimidine-5-ol 5-methoxypyrimidin-2-amine 2-(4-chloro-phenyl)-5-methoxy-pyrimidine 5-methoxy-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrimidine

2,4-二氯-5-甲氧基嘧啶置于水,锌体系中,用 乙醇 用作溶剂,化学反应 4.0H,以58%的收率获得2-氯-5-甲氧基嘧啶
参考文献: Compounds[fr] Composés
标题: Compounds[fr] Composés
摘要:提供具有以下结构的化合物或其药学上可接受的盐或前药:其中r1为cn;R2为h或f;R3和r4独立地为氢,氟,氯或or8;R5为氢,C1-6烷基,C1-6烯基或c1-6炔基;R6和r7独立地为氢,卤素,Or8或nr9R10;R8为氢或c1-6烷基;R9和r10独立地为氢或c1-6烷基;或当它们连接到氮原子时,基团r9和r10可以共同形成一个选自nr8,S和o的另外一个杂原子的5-或6-成员环,该5或6-成员环可选择地被羟基或c1-6烷氧基取代;或当它们连接到氮原子时,基团r9和r10可以共同形成一个可选择地被羟基或c1-6烷氧基取代的氮杂环丙烷环.还公开了这些化合物在治疗与淀粉样蛋白相关疾病中的用途.

专利信息

专利号:US-2008280877-A1
优先权日:2007-05-10
标 题:Azetidines
发明人：DACK KEVIN NEIL; SKERRATT SARAH ELIZABETH; YEAP SIEW KUEN
权利人:PFIZER
摘要:The invention relates to EP2 antagonist azetidines of formula (I) n n n n n n n n n n wherein Ar, R 1 , X, and Z are as defined herein, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids, to intermediates useful in their synthesis, and to compositions containing them.