CAS: 301222-66-2; 2-Amino-5-Fluoro-4-Picoline

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1628184-28-0 1003710-35-7 475060-22-1

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号21901-40-6 2-氨基-4-甲基-5-硝基吡啶 | CAS号90765-02-9 4-甲基-2-乙酰氨基-5-硝基吡啶 | CAS号475060-21-0 N-(5-氟-4-甲基吡啶-2... | CAS号475060-18-5 4-甲基-2-乙酰氨基-5-氨基吡啶

4-甲基-2-乙酰氨基-5-氨基吡啶置于盐酸,Tetrafluoroboric Acid,Sodium Nitrite体系中,用 乙醇,甲苯 作为反应溶剂,化学反应生成 4-甲基-2-氨基-5-氟吡啶
参考文献:Mexab-Oprm Specific Efflux Pump Inhibitors In Pseudomonas Aeruginosa. Part 4: Addressing The Problem Of Poor Stability Due To Photoisomerization Of An Acrylic Acid Moiety
标题:Mexab-Oprm Specific Efflux Pump Inhibitors In Pseudomonas Aeruginosa. Part 4: Addressing The Problem Of Poor Stability Due To Photoisomerization Of An Acrylic Acid Moiety
摘要:Exchange Of The Ethylene Tether In A Series Of Pyridopyrimidine-Based Mexab-Oprm Specific Efflux Pump Inhibitors To An Amide Bond Stabilized The Olefin Of The Acrylic Acid Moiety,Preventing Facile Photoisomerization To The Z-Isomer. Furthermore,The Activity Was Drastically Improved In The Amide Tether Variants,Providing Extremely Potent Acrylic Acid And Vinyl Tetrazole Analogues. (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2004.03.007

专利信息

专利号:US-11731956-B2
优先权日:2018-10-22
标 题:Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors