CAS: 3308-94-9; 2-(3-Chloropropyl)-2-(4-Fluorophenyl)-1,3-Dioxolane

上下游产品

CAS号107-21-1 乙二醇 | CAS号3874-54-2 4-氯-4'-氟苯丁酮 | CAS号3874-54-2 4-氯-4'-氟苯丁酮 | CAS号2560-31-8 1-(4-FLUORO-PHE... | CAS号55846-41-8 1-{3-[2-(4-氟苯基)... | CAS号52-86-8 氟哌啶醇 | CAS号57648-21-2 替米哌隆 | CAS号56660-98-1 1-[3-[2-(4-fluo... | CAS号56660-99-2 4-(p-Chlorophen... | CAS号57718-48-6 N-[1-[3-[2-(4-f... | CAS号54080-21-6 8-[3-[2-(4-fluo...

4-氯-4'-氟苯丁酮置于对甲苯磺酸体系中,用 乙二醇,苯 用作溶剂,以57.7 G (93%)的收率获得2-(3-氯丙基)-2-(4-氟苯基)-1,3-二氧戊烷
参考文献:Antipsychotic 1-Fluorophenylbutyl-4-(2-Pyrimidinyl)Piperazine Derivatives
标题:Antipsychotic 1-Fluorophenylbutyl-4-(2-Pyrimidinyl)Piperazine Derivatives
摘要:二取代n,N-哌嗪基衍生物被披露,其中一个取代基是嘧啶-2-基环,另一个是连接到对氟苯基环的末端碳上的4碳链.这个丁二烯链的末端碳也与一个氧原子结合,作为羰基,醇基或缩醛功能团的一部分.这些化合物具有精神药理特性,特别是非常好持续时间的非典型抗精神病活性.通过临床前药理学测试,这些化合物似乎有望作为潜在的抗精神病药物,而不具有标准抗精神病药物的典型运动障碍副作用.

专利信息

专利号:US-5817690-A
优先权日:1996-08-27
标 题:4-aminoethoxy indolone derivatives
发明人：MEWSHAW RICHARD ERIC
权利人:AMERICAN HOME PROD
摘要:A compound of the formula I: I in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or -(CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

专利号:EP-0923551-B1
优先权日:1996-08-27
标题:4-aminoethoxy indolone derivatives
发明人：MEWSHAW RICHARD ERIC
权利人:AMERICAN HOME PROD
摘要:A compound of formula (I) in which Y is hydrogen, halogen or lower alkoxy; R1 is hydrogen, lower alkyl or aryl(lower)alkyl; R2 is hydrogen, lower alkyl or -(CH2)nXpAr, where X is oxygen or carbonyl; Ar is cycloalkyl, aryl or arylaryl, oxindolyl, benzimidazolyl, indolyl, 2-oxobenzimidazolyl or 2-thioxobenzimidazolyl; or R1 and R2, taken together with the nitrogen atom to which they are attached, complete a 3,4-dihydro-1H-isoquinolinyl or 1,3-dihydro-isoindolyl; n is one of the integers 1,2,3,4,5 or 6; p is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.