CAS: 3828-49-7; 1,2-Difluoro-3-Methylbenzene

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CAS号446-57-1 2,3-二氟氯苄 | CAS号847502-81-2 6-溴-2,3-二氟甲苯 | CAS号157652-31-8 3,4-二氟-2-甲基苯甲酸 | CAS号2646-91-5 2,3-二氟苯甲醛 | CAS号1251156-08-7 [7-(6-氨基-3-吡啶基)... | CAS号118939-18-7 3-氟-2-甲基-4-(甲基磺...

4-Chloro-3-Methyl-4,5,5-Trifluorocyclohexene置于sodium Hydroxide,苄基三乙基氯化铵体系中,化学反应生成2,3-二氟甲苯
参考文献:Method Of Preparing Fluoroaromatic Compounds
标题:Method Of Preparing Fluoroaromatic Compounds
摘要:本发明提供了一种制备邻二氟苯衍生物的方法,包括(A)通过在流动反应器中将氯三氟乙烯(ctfe)和1,3-二烯反应并提供环己烯混合物,然后蒸馏所得产物,以及(B)在无有机溶剂的情况下,使用相变催化剂在碱金属氢氧化物的存在下,将环己烯混合物在40至150摄氏度的温度范围内脱氢卤化.在蒸馏所得产物时,获得的低沸点馏分被回收至流动反应器中.本发明还提供了一种制备2-氯-4,5-二氟苯甲酸的方法,包括(A)通过将氯三氟乙烯(ctfe)和异戊二烯反应并提供4-氯-1-甲基-4,5,5-三氟环己烯和5-氯-1-甲基-4,4,5-三氟环己烯的混合物,然后蒸馏所得产物,(B)在碱金属氢氧化物和相变催化剂的存在下,将所述混合物脱氢卤化以形成3,4-二氟甲苯,(C)在无有机溶剂的情况下,将所述3,4-二氟甲苯与氯气反应以形成2-氯-4,5-二氟甲苯,(D)在无有机溶剂的情况下,在光照汞灯下将所述2-氯-4,5-二氟甲苯与氯气光反应以形成2-氯-4,5-二氟苯三氯甲烷,以及(E)在无有机溶剂的情况下,将所述2-氯-4,5-二氟苯三氯甲烷与水酸溶液反应.本发明还提供了一种通过将上述步骤(E)中的2-氯-4,5-二氟苯三氯甲烷与氧化锌反应来制备2-氯-4,5-二氟苯甲酰氯的方法.

专利信息

专利号:WO-2025217610-A1
优先权日:2024-04-12
标题:Systems and methods for enzymatic oligonucleotide synthesis
发明人：ENTWISTLE DAVID; GAUNTLETT DEREK; MILLER MICHAEL; REEVES RYAN; WATTS DAVID
权利人:CODEXIS INC
摘要:The present invention provides for methods and systems for template-free synthesis of an oligonucleotide, and methods of using the systems as disclosed herein for template-free synthesis of an oligonucleotide.

专利号:WO-2010144293-A1
优先权日:2009-06-08
标 题 :Synthesis of telcagepant and intermediates thereof
发明人：XU FENG; DESMOND RICHARD; HOERRNER R SCOTT; HUMPHREY GUY R; ITOH TETSUJI; JOURNET MICHEL; YOSHIKAWA NAOKI; ZACUTO MICHAEL J
权利人:MERCK SHARP & DOHME; XU FENG; DESMOND RICHARD; HOERRNER R SCOTT; HUMPHREY GUY R; ITOH TETSUJI; JOURNET MICHEL; YOSHIKAWA NAOKI; ZACUTO MICHAEL J
摘要:Disclosed is an efficient synthesis for the manufacture of the caprolactam intermediate (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one: Formula and salts thereof, and an efficient preparation of telcagepant using the caprolactam intermediate.

专利号:US-8735391-B2
优先权日:2008-09-26
标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods
发明人：AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J
权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS
摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.

专利号:US-12319944-B2
优先权日:2017-07-11
标题 :Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; CAFFARO CAROLINA; AERNI HANS; ZHANG YORKE; FISCHER EMIL C; FELDMAN AARON W; DIEN VIVIAN T; ROMESBERG FLOYD E
权利人:SYNTHORX INC; SCRIPPS RESEARCH INST
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-5087764-A
优先权日:1988-03-10
标 题 :Process for the preparation of 2,3-difluorobenzenes
发明人：REIFFENRATH VOLKER; KRAUSE JOACHIM
权利人:MERCK PATENT GMBH
摘要:1,4-disubstituted 2,3-difluorobenzenes according to formula I are suitable as intermediates for the synthesis of liquid crystalline compounds.

专利号:US-2023130423-A1
优先权日:2020-02-12
标题:Novel mrna 5'-end cap analogs, rna molecule incorporating the same, uses thereof and method of synthesizing rna molecule or peptide
发明人：WARMINSKI MACIN; SIKORSKI PAWEL; KOWALSKA JOANNA; JEMIELITY JACEK
权利人:UNIV WARSZAWSKI; EXPLORNA THERAPEUTICS SP Z O O
摘要:The invention relates to new mRNA 5′ end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method encompasses translation of the RNA molecule.