专利号:US-2005239767-A1 优先权日:2003-10-28 标题 :Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands 发明人:CHAN MICHAEL K; FEKNER TOMASZ 权利人:CHAN MICHAEL K; FEKNER TOMASZ 摘要:A new class of tetracylic benzimidazole compounds and derivatives thereof. Additionally provided is a synthetic route for the generation of these and related compounds via Intramolecular Aromatic Nucleophilic Substitution (S N Ar) of the Benzimidazole-Activated Nitro Groups. Additionally, a facile route for the generation of novel phenol species as thermal decomposition of compounds the S N Ar product, which occurs at high temperature resulting in cleavage of the ether linkage and formation of a vinyl group and phenol is provided. Also provided are methods of using the compounds described herein in the treatment HIV.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:RU-2136285-C1 优先权日:1996-04-23 标题:Method of synthesis of drug nitrazepam - 1,3-dihydro-5-phenyl-7-nitro-2h-1,4-benzodiazepine-2-one
专利号:CN-109467525-A 优先权日:2017-12-31 标题:A kind of DTNB total synthesis method
专利号:CN-104059103-B 优先权日:2014-05-08 标 题 :Synthesis method of arylphosphate compounds
[参考文献]: Tadashi Kataoka, Et Al. Synthesis And Structure-Activity Relationships Of Thioflavone Derivatives As Specific Inhibitors Of The Erk-Map Kinase Signaling Pathway. Bioorg Med Chem. 2004 May 1;12(9):2397-407.
合成参考文献
参考文献:10.1007/978-3-030-29541-7_15 摘要:Mäkelä MR, Hildén K, Kowalczyk JE, Hatakka A. Progress and Research Needs of Plant Biomass Degradation by Basidiomycete Fungi. 2020. In: Grand Challenges in Biology and Biotechnology. 参考文献:10.1007/978-981-99-0260-6_8 摘要:Yamanoi Y, Omoto K, Nakae T, Nishio M. Thermosalient Phenomena in Molecular Crystals: A Case Study of Representative Molecules. 2023. In: The Materials Research Society Series.