CAS: 65169-38-2; 2-Chloro-4-Methylpyridine-3-Carbonitrile

相似化合物

152362-01-1 875-35-4 66909-35-1

上下游产品

CAS号93271-59-1 2-羟基-4-甲基吡啶-3-甲腈 | CAS号875-35-4 2,6-二氯-4-甲基-3-吡啶氰 | CAS号13166-10-4 异亚丙基丙二腈 | CAS号5444-02-0 2,6-二羟基-3-氰基-4-甲基吡啶 | CAS号133627-45-9 2-氯-3-氨基-4-甲基吡啶 | CAS号152362-01-1 2-氯-4-甲基烟酰胺

异亚丙基丙二腈置于盐酸,乙酸酐体系中,用 溶剂黄146,甲苯 作为反应溶剂,化学反应 3.0H,反应生成 2-氯-3-氰基-4-甲基吡啶
参考文献:由亚炔基丙二腈改进的单和双取代2-卤代锡腈的合成
标题:由亚炔基丙二腈改进的单和双取代2-卤代锡腈的合成
摘要:具有2,3,4和/或5取代基的吡啶仍然难以制备.现有的通过烯胺形成多取代的2-卤代丁腈的策略遭受起始亚烷基丙二腈的二聚作用,导致收率低.通过改变反应条件,通过在亚化学计量的乙酸酐存在下使dmf-Dma和亚烷基丙二腈缩合,实现了一种新的高产率烯胺化方法.在pinner条件下环化所得的烯胺以高总收率提供了2-卤代丁腈.
DOI:10.1021/ol4025265

专利信息

专利号:WO-2016118586-A1
优先权日:2015-01-20
标 题 :Lowcost, high yield synthesis of nevirapine
发明人：AHMAD SAEED; GUPTON FRANK; VERGHESES JENSON; MCQUADE TYLER
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Improved methods of producing the HIV drug substance, nevirapine are provided. The methods employ a cost effective and high yield synthetic methods for preparing the nevirapine building block 2-chloro-3-amino-4-picoline (CAPIC) and 2-cyclopropyl amino nicotinate (Me-CAN), and improvements in other steps of nevirapine synthesis.

专利号:US-6111112-A
优先权日:1999-01-22
标题 :Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone
发明人：GROZINGER KARL
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A method for making 3-amino-2-chloro-4-methylpyridine from malononitrile, as depicted in the following reaction scheme. ##STR1##

专利号:WO-0043365-A1
优先权日:1999-01-22
标 题:Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone

专利号:EP-1064265-A1
优先权日:1999-01-22
标 题 :Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone

专利号:JP-2002535311-A
优先权日:1999-01-22
标 题 :Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone

专利号:EP-1064265-B1
优先权日:1999-01-22
标 题 :Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone