CAS: 79-31-2; Isobutyric Acid

上下游产品

CAS号74-98-6 丙烷 | CAS号201230-82-2 carbon monoxide | CAS号78-84-2 异丁醛 | CAS号79-41-4 甲基丙烯酸 | CAS号78-83-1 异丁醇 | CAS号1759-53-1 环丙甲酸 | CAS号869563-40-6 (4S)-4-benzyl-3... | CAS号75-29-6 2-氯丙烷 | CAS号75-28-5 异丁烷 | CAS号124-38-9 二氧化碳 | CAS号10457-59-7 14-Isopropyldib... | CAS号5851-43-4 2-异丙基苯并咪唑 | CAS号5471-77-2 2,2-二甲基丙二酸单乙酯 | CAS号595-46-0 二甲基丙二酸 | CAS号595-37-9 2,2-二甲基丁酸 | CAS号813-72-9 2,2-二甲基己酸 | CAS号14250-88-5 2,2-二甲基戊醛 | CAS号478296-72-9 1-[[[[1-(2-甲基-1... | CAS号492-37-5 2-苯基丙酸 | CAS号19136-93-7 异丁酸-D1

异丁酸异丁酯置于盐酸体系中,用 丙酮 作为反应溶剂,化学反应 4.0H,以87%的收率获得产物异丁酸
参考文献: Processes For Producing Carboxylic Acids[fr] Procédés De Production D'Acides Carboxyliques
标题: Processes For Producing Carboxylic Acids[fr] Procédés De Production D'Acides Carboxyliques
摘要:公开了从有机酯制备羧酸的过程,该过程包括在酸催化剂和均相溶剂存在下将酯与水接触,以形成羧酸的有效条件.均相溶剂以足够量存在,以形成包括酯,水和均相溶剂的单相反应混合物.均相溶剂可以选择自乙腈,二甲基亚砜和1,4-二氧六环.

专利信息

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2008119665-A1
优先权日:2004-09-07
标 题:Process for the Synthesis of Zirconium Carboxylates
发明人：FRITZ PETER; BOLT HEINZ; SCHERSCHLICHT KARL-HEINZ; MOSA FUAD; ALI TALAL K; AL-OTAIBI SULTAN
权利人:FRITZ PETER; BOLT HEINZ; SCHERSCHLICHT KARL-HEINZ; MOSA FUAD; ALI TALAL K; AL-OTAIBI SULTAN
摘要:A process for the synthesis of zirconium tetra carboxylates is disclosed. To overcome the disadvantageous characteristics of the currently used production process, which include highly corrosive starting substances and products, and complex removal of HCl, ZrCI 4 is suspended in an apolar solvent and reacted with the anhydride of an organic acid. The sole products of this reaction are slightly corrosive Zr tetra carboxylate and an organic acid chloride, which is a valuable basic chemical in the chemicals and pharmaceuticals industry. The reactors required for the synthesis need not necessarily consist of glass and/or enamel, but may instead be manufactured from stainless steel, which is cheaper. Apparatuses for the removal and treatment of hydrochloric acid are not necessary.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.