CAS: 80307-12-6; 2,5-Dioxopyrrolidin-1-Yl 4-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Butanoate

相似化合物

103750-03-4 55750-63-5 87981-04-2

上下游产品

1-hydroxy-pyrrolidine-2,5-dione 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl chloride (21),4,6,10,18-pentaen-9-yl esterCarbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-19-{4-[4-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-butyrylamino]-butylamino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]d°Cosa-1(21),4,6,10,18-pentaen-9-yl ester 64H74ClN11O13C64H74ClN11O13

4-(3-Carboxypropylamino)-4-Oxobut-2-Enoic Acid置于氯化亚砜,三正丁胺,N,N-二异丙基乙胺,对硝基三氟乙酸苯酯体系中,用 乙腈 作为反应溶剂,化学反应 9.0H,反应生成 4-马来酰亚胺基丁酸-N-琥珀酰亚胺酯
参考文献:合成n-马来酰亚胺基烷基酸及其琥珀酰亚胺 酯的方法
标题:合成n-马来酰亚胺基烷基酸及其琥珀酰亚胺 酯的方法
摘要:本发明提供了一种合成n‑马来酰亚胺基烷基酸及其琥珀酰亚胺酯的方法,该方法包括以下步骤:(A)式(II)化合物与4‑硝基三氟乙酸苯酯在碱存在的条件下,在有机溶剂中发生关环反应,得到式(Iii)的n‑马来酰亚氨基烷基酸;及(B)式(Iii)的n‑马来酰亚氨基烷基酸与酰化试剂在有机溶剂中,在回流温度下反应得到(Iv)的酰氯中间体,(Iv)的酰氯中间体与n‑羟基琥珀酰亚胺在有机溶剂中,在碱存在的条件下发生反应,得到式(V)的n‑马来酰亚胺基烷基酸琥珀酰亚胺酯.该方法工艺简单,收率高,且产品纯度高,适合工业化生产.反应路线如下:

专利信息

专利号:US-2024024489-A1
优先权日:2020-11-20
标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
发明人：MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
权利人:PASTEUR INSTITUT
摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

专利号:US-2008145899-A1
优先权日:2004-09-17
标题 :Production of Oligosaccharides By Microorganisms
发明人：JOHNSON KARL; BYRNE NOEL J; DEFREES SHAWN
权利人:NEOSE TECHNOLOGIES INC
摘要:The present invention relates to the enzymatic synthesis of oligosaccharides, including sialylated product saccharides. In particular, it relates to the use of recombinant cells to take up low cost precursors such as glucose, pyruvate and N-actyl-glucosamine, and to synthesize activated sugar moieties that are used in oligosaccharide synthesis. The methods make possible the synthesis of many oligosaccharides using microorganisms and readily available, relatively inexpensive starting materials.

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:WO-03064360-A1
优先权日:2002-02-01
标 题:Synthetic tetraethers and synthesis strategies therefor
发明人：KUEHL CHRISTINE; LITTGER RALF
权利人:BERNINA BIOSYSTEMS GMBH; KUEHL CHRISTINE; LITTGER RALF
摘要:The invention relates to novel synthetic tetraethers and a novel method for producing said substances. The inventive tetraethers are characterised in that they can be modified in a simple and targeted manner according to said synthesis method, which enabling the synthesis of the desired model substances. The synthesis concept guarantees high variability with simple individual production.

专利号:US-8647823-B2
优先权日:2005-07-22
标 题 :Polynucleotide synthesis on a modified surface
发明人：PARK JOON-WON; HONG BONG-JIN
权利人:PARK JOON-WON; HONG BONG-JIN; POSTECH FOUNDATION; POSCO
摘要:The present invention relates to a method for the synthesis of a polynucleotide on a modified surface of a substrate, wherein the modified surface is obtained by chemically modifying with macromolecules in which a plurality of termini of the branched region are bound to the surface and a terminus of the linear region is functionalized.

专利号:US-10254287-B2
优先权日:2015-07-21
标题 :Protein fluorescent nanoparticles and methods of synthesis thereof
发明人：KUMAR CHALLA VIJAYA; STROMER BOBBI SHANYELLE
权利人:UNIV CONNECTICUT
摘要:Disclosed herein are stable and versatile protein nanoparticles having a range of tunable fluorescent properties. Such nanoparticles may find utility in biological imaging. Methods of synthesis of such nanoparticles are also disclosed.