CAS: 1019-71-2; Chlorodi-P-Tolylphosphane

相似化合物

74289-57-9 1079-66-9 13685-23-9

上下游产品

CAS号2409-61-2 双(|p|-甲苯基)氧化磷 | CAS号683-85-2 二氯(二甲氨基)膦 | CAS号696-61-7 对甲苯基氯化镁 | CAS号106-38-7 对溴甲苯 | CAS号108-88-3 甲苯 | CAS号1060-21-5 1-[bis(4-methyl... | CAS号99646-28-3 (|R|)-(+)-2,2'-... | CAS号2409-61-2 双(|p|-甲苯基)氧化磷 | CAS号1017-60-3 双对甲基苯基膦

三对苯甲基膦置于zinc Trifluoromethanesulfonate,三氯化磷体系中,用 四氯化碳 用作溶剂,化学反应 12.0H,以91%的收率获得p,P-双(4-甲基苯基)-氯化膦 氯二对甲苯基膦
参考文献:一种二芳基磷氯化合物的制备方法
标题:一种二芳基磷氯化合物的制备方法
摘要:本发明公开了一种二芳基磷氯化合物的制备方法,属于有机合成领域.该方法以三芳基磷为起始原料,三氟甲烷磺酸锌为催化剂,与三氯化磷反应后经蒸馏得到芳基磷氯化合物.本发明与现有技术相比反应收率高,后处理简单,特别适合带有取代基的二芳基磷氯化合物的制备,更适合工业化生产.制得的芳基磷氯化合物可用于合成金属催化剂的配体,应用于有机光电材料及医药等领域.

专利信息

专利号:US-9518014-B2
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process
发明人：DING KUILING; WANG XIAOMING; WANG ZHENG
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of β-arylamino α-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of β-arylamino α-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.

专利号:US-2015166479-A1
优先权日:2012-07-20
标 题 :Process for synthesis of ezetimibe and intermediates used in said process

专利号:EP-2876102-A1
优先权日:2012-07-20
标 题 :Process for synthesis of ezetimibe and intermediates used in said process

专利号:EP-2876102-B1
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process